| 胰腺癌细胞系血管紧张素Ⅱ1型受体蛋白表达的研究 |
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| 引用本文： | 江华 李兆申 等. 胰腺癌细胞系血管紧张素Ⅱ1型受体蛋白表达的研究[J]. 胰腺病学, 2003, 3(1): 39-41 |
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| 作者姓名： | 江华 李兆申 等 |
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| 作者单位： | 第二军医大学长海医院消化内科，上海200433 |
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| 摘 要： | 目的：探讨血管紧张素Ⅱ1型受体（angiotensin Ⅱ type 1 receptor,AT1）在胰腺癌细胞中的表达。方法：用免疫细胞化学染色检测胰腺癌细胞系SW1990、PaTu8988s和PANC－1中AT1蛋白的表达。结果：胰腺癌细胞系SW1990、PaTu8988s和PANC－1中均有AT1蛋白的表达，结论：AT1在胰腺癌细胞生长中可能发挥重要作用，应用AT1拮抗剂对防治胰腺癌似乎有一定意义。
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| 关 键 词： | 胰腺癌 血管紧张素Ⅱ 血管紧张素Ⅱ1型受体 |
| 修稿时间： | 2002-07-29 |
Expression of angiotensin II type 1 receptor protein in human pancreatic cancer cell lines. |
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| JIANGHua,LI Zhaoshen,XU Guoming,et al.. Expression of angiotensin II type 1 receptor protein in human pancreatic cancer cell lines.[J]. Chinese JOurnal of Pancreatology, 2003, 3(1): 39-41 |
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| Authors: | JIANGHua LI Zhaoshen XU Guoming et al. |
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| Affiliation: | JIANGHua,LI Zhaoshen,XU Guoming,et al. Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective To investigate the expression of angiotensin I type 1 receptor (AT1) in pancreatic cancer cell lines. Methods ABC immunocytochemical staining was used to detect AT1 protein expression in three pancreatic cancer cell lines SW1990, PaTu 8988s and PANC-1. Results AT1 protein expressed in the three pancreatic cancer cell lines. Conclusions AT1 may play an important role in pancreatic cancer growth. Furthermore, use of AT1 antagonists may be of significance for the prevention and treatment of pancreatic cancer. |
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| Keywords: | Angiotensin II Pancreatic neoplasms Angiotensin II type 1 receptor |
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