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| 冰片和川芎嗪血药浓度的GC－MSD测定法 | |
| 引用本文： | 杨丽莉,袁倚盛,佟永岭,郭长源. 冰片和川芎嗪血药浓度的GC－MSD测定法[J]. 药学学报, 1994, 0(9) |
| 作者姓名： | 杨丽莉 袁倚盛 佟永岭 郭长源 |
| 作者单位： | 南京军区总医院中心仪器分析科，天津第六中药厂 |
| 摘 要： | 建立了用气相色谱—质谱检测法同时测定血浆中冰片和川芎嗪血药浓度的方法。冰片和川芎嗪浓度在１０～３００ｎｇ／ｍｌ范围内线性关系良好。冰片和川芎嗪的血中回收率分别为９７．３２％和８７．３７％；最低检测浓度为２ｎｇ／ｍｌ。本方法以樟脑为内标，ＳＩＭ方式检测，定量准确、干扰小，日内及日间的相对标准偏差分别小于４％和７％。并应用本法成功地进行了动物实验和健康人含服速效救心丸后冰片的药代动力学研究。 |
| 关 键 词： | 冰片，川芎嗪，气相色谱—质谱检测法，药代动力学 |
DETERMINATION OF TETRAMETHYLPYRAZINE AND BORNEOL IN HUMAN PLASMA BY GC-MSDLL |
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| Yang,YS Yuan,YL Tong and CY Guo. DETERMINATION OF TETRAMETHYLPYRAZINE AND BORNEOL IN HUMAN PLASMA BY GC-MSDLL[J]. Acta pharmaceutica Sinica, 1994, 0(9) | |
| Authors: | Yang YS Yuan YL Tong CY Guo |
| Affiliation: | Yang,YS Yuan,YL Tong* and CY Guo * |
| Abstract: | A GC-MSD method fot the determination of tetramethylpyrazine(TMP)andborneol in plasma is described.TMP and borneol were extracted with hexane dichloromethane(10:1,V/V).Camphor was used as the internal standard.The average recoveries of TMP and borneolwere 87.38%and 97.32/with relative standard deviation 1.96%to 6.21%,respectively.Themethod was succassfully used to determine plasma borneol concentration following sublingual adminis-tration of 20 pills of Suxiao Jiuxin Wan to healthy volunteers(n=10).The pharmacokineticparameters have been listed in this paper. |
| Keywords: | Tetramethylpyrazine(TMP) Borneol GC-MSD Pharmacokinetics |
| 本文献已被 CNKI 等数据库收录！ | |