小剂量辛伐他汀对慢性阻塞性肺疾病合并肺动脉高压患者的影响

目的研究辛伐他汀对慢性阻塞性肺疾病合并肺动脉高压患者疗效的影响,探讨其对患者肺动脉压、肺功能、血气分析、一氧化氮以及超敏C反应蛋白的水平变化影响。方法将60例慢性阻塞性肺疾病合并肺动脉高压患者随机分为治疗组和对照组,治疗组在常规治疗的基础上加用辛伐他汀20mg,每晚1次,对照组给予安慰剂治疗,疗程为1个月。治疗前后检测患者肺功能、血气分析、一氧化氮以及超敏C反应蛋白的水平。结果治疗组总有效率83.33%,高于对照组的66.67%,差异有统计学意义(P<0.05);治疗组肺动脉压、血气、肺功能的改善较对照组更明显,血清中一氧化氮、hs-CRP水平明显降低,与治疗前及对照组比较差异有统计学意义(P<0.05)。结论辛伐他汀治疗慢性阻塞性肺疾病合并肺动脉高压患者疗效确切,值得临床推广应用。

Effect of Low Dose Simvastatin in Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Arterial Hypertension

Objective To study the effects of simvastatin on pulmonary arterial pressure, pulmonary function, blood gas analysis, nitric oxide and high sensitivity C-reactive protein level changes. in patients with chronic obstructive pulmonary disease complicated with pulmonary arterial hypertension. Methods Sixy cases of patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension were randomly divided into the treatment group and the control group. The treatment group based on routine treatment plus simvastatin 20mg, night time, and the control group was given placebo treatment, treatment for 1 months. Before and after treatment,pulmonary function test, blood gas analysis, nitric oxide and high sensitivity C-reactive protein level were detected. Results The total effective rate of treatment group was 83.33%, higher than 66.67% in the control group,and the difference was statistically significant (P<0.05). Pulmonary arterial pressure, blood gas analysis, pulmonary function improvement in treatment group were better than the control group obviously, and nitric oxide, hs-CRP level in the serum decreased significantly, with statistical significance before and after treatment and control group were (P<0.05). Conclusion Simvastatin is safe and effective in treating hypertension in patients with chronic obstructive pulmonary disease complicated with pulmonary artery.It is worthy of clinical application.