冠状动脉粥样硬化心脏病患者外周血Ghrelin、obestatin水平变化及意义

目的 观察冠状动脉粥样硬化心脏病（CHD）患者空腹外周血Ghrelin、obestatin水平的变化,并探讨其临床意义。方法 选取92例行冠状动脉造影住院患者,根据造影结果分为对照组21例和冠状动脉粥样硬化组71例,计算冠状动脉粥样硬化组患者的Gensini积分,检测两组患者的血清Ghrelin、obestatin水平,并分析Ghrelin、obestatin水平与Gensini积分之间的相关性。结果 冠状动脉粥样硬化组Ghrelin水平较对照组显著降低（P＜0.01）,而obestatin水平较对照组显著升高（P＜0.01）。根据Gensini积分将冠状动脉粥样硬化组患者分为1～30分组、31 ～90分组及＞90分组。血清Ghrelin水平随Gensini积分增加而降低,而各组间血清obestatin浓度差异无统计学意义（P＞0.05）。结论 CHD患者的血清Ghrelin水平与冠状动脉病变程度显著相关,而obestatin水平与CHD患者病变程度无显著性关系。推测Ghrelin可能是CHD的一个重要保护因子,而obestatin可能是CHD的一个危险因子。

Coronary Atherosclerotic Heart Disease Changs of Ghrelin,Obestatin Levels and Its Significance in Patients

Objective To observe the changes of Ghrelin,obestatin levels in fasting peripheral blood in coronary atherosclerotic heart disease（CHD） patients,and explore its clinical significance.Methods The 92 hospitalized patients underwent coronary angiography were selected.According to the results of angiography,they were divided into 21 cases of control group and 71 cases of coronary atherosclerosis group.The Gensini score of coronary atherosclerosis group patients was calculated.detect The levels of serum Ghrelin were detected.The correlation between Ghrelin,obestatin levels and Gensini integral was analyzed.Results The level of Ghrelin in coronary atherosclerosis group was significantly lower than the control group（P ＜ 0.01）,while the level of obestatin was significantly higher than those in control group（P ＜ 0.01）.According to the Gensini integral,coronary atherosclerosis group were divided into 1-30 group,31-90 group and ＞90 group.The serum level of Ghrelin decreased with the increase of Gensini integral,but there was no significant difference in serum obestatin concentration between groups（P ＞ 0.05）.Conclusion The level of serum Ghrelin in patients with CHD were significantly related with the severity of coronary artery disease,and the level of obestatin and severity of CHD patients had no significant relationship.It suggests that Ghrelin may be an important protective factor for CHD,while obestatin may be a risk factor for CHD.