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| Reversing Effects of DDPH on Cardiac Hypertrophy andIncreased Collagen Content Induced by Partial Narrowing of Abdominal Aorta | |
| 引用本文： | 张志兵,李薇,钱家庆. Reversing Effects of DDPH on Cardiac Hypertrophy andIncreased Collagen Content Induced by Partial Narrowing of Abdominal Aorta[J]. 华中科技大学学报(医学英德文版), 1997, 17(3): 147-150. DOI: 10.1007/BF02888290 |
| 作者姓名： | 张志兵 李薇 钱家庆 |
| 作者单位： | Department of Pharmacology，Tongji Medical University，Wuhan，430030 |
| 摘 要： | Cardiachypertrophycouldbecausedbymanyphysicalandchemicalstimulation.Whencardiachypertrophydevelops,notonlythesizeofmyocardialcellsincrease,butmatrixsuchascollagenalsosufferfromhyperplasia['Jandcardiacfunctionisimpaired.Mortalityrateisveryhighbecauseofcardiacfailureandsuddendeath[2].So,itisofgreatimportancetostudythemechanismofcardiachypertrophyanddrugsthatcanreversecardiachypertrophy.IthasbeenreportedthatmanydrugssuchasACEI[3],calciumantagonists[']andalblockingagents[sjcouldreversecardiachyp… |
| 收稿时间： | 1996-07-09 |
Reversing effects of DDPH on cardiac hypertrophy and increased collagen content induced by partial narrowing of abdominal aorta |
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| Zhang Zhibing,Li Wei,Qian Jiaqing. Reversing effects of DDPH on cardiac hypertrophy and increased collagen content induced by partial narrowing of abdominal aorta[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1997, 17(3): 147-150. DOI: 10.1007/BF02888290 | |
| Authors: | Zhang Zhibing Li Wei Qian Jiaqing |
| Affiliation: | (1) Department of Pharmacology, Tongji Medical University, 430030 Wuhan |
| Abstract: | To investigate the reversing effects of DDPH on cardiac hypertrophy and increased collagen content in left ventricle tissue of rats, cardiac hypertrophy of rats were induced by partial narrowing of abdominal aorta. 4 weeks after operation, the rats were given DDPH for 8 weeks. 12 weeks later, it was found that in model group, LVW/WHW and WHW/BW increased by 39. 0 % and 36. 9 % than those in control group; collagen content increased by 1. 5 times. I/E, LS decreased (P<0. 01), MMW/E. WZ increased (P<0. 01). The above-mentioned changes in two DDPH groups could be partly or completely reversed. It is concluded that DDPH could reverse cardiac hypertrophy of rats induced by partial narrowing of abdominal aorta and reduce collagen content in left ventricle tissue. |
| Keywords: | cardiac hypertrophy DDPH collagen |
| 本文献已被 CNKI SpringerLink 等数据库收录！ | |