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The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option |
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| Authors: | Antonio Siniscalchi Antonello Bonci Bonci Nicola Biagio Mercuri Domenico Pirritano Aida Squillace Giovambattista De Sarro Luca Gallelli |
| Affiliation: | 1.Department of Neurology, “Annunziata” Hospital, Cosenza, Italy;;2.Intramural research program, National Institute on Drug Abuse, NIH, Baltimore, 21224, USA;;3.IRCCS-FondazioneS. Lucia and Department of Neurophysiopathology University “Tor Vergata”, Rome, Italy; ;4.Diagnostic Center Igea SRL, Catanzaro;;5.Diagnostic Center Igea SRL, Catanzaro; |
| Abstract: | Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological andpsychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibitsglutamatergic transmission (i.e. AMPA/kainate receptors).Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocainereinforcement. Therefore, TPM could be used in the management of cocaine dependence. |
| Keywords: | Cocaine dependence gamma-aminobutyric acid neurotransmission glutamatergic neurotransmission topiramate. |