胃肠道间质瘤的临床病理和免疫组织化学特征

目的探讨胃肠道间质瘤(GIST)的临床病理以及免疫组织化学特征。方法回顾性分析72例GIST患者的临床资料。结果 72例GIST患者的肿瘤部位为:25例(34.7%)胃部,24例(33.3%)小肠,23例(31.9%)其他部位。镜下显示主型为梭形细胞68例(94.4%),主型为上皮样细胞1例(1.4%),混合细胞型3例(4.2%)。免疫组化检查显示,71例(98.6%)CD117阳性,52例(72.2%)CD34阳性,22例(30.6%)SMA阳性,1例(1.4%)Desmin阳性,6例(8.3%)S-100阳性。结论 GIST的发病部位较多,组织形态学表现复杂,联合应用免疫组化检查有助于临床诊断与鉴别。

Clinical pathological and immunohistochemical features of gastrointestinal stromal tumors

Objective To investigate the clinical pathological and immunohistochemical features of gastrointestinal stromal tumors （GIST）. Methods Seventy-two patients with GIST were retrospectively analyzed. Results All the pa- tients with GIST, 25 cases （34.7%） of the stomach, 24 cases （33.3 % ） of small intestine, 23 cases （31.9% ） of oth- er sites. Microscope showed that the main type of spindle cell in 68 cases （94.4%） , the main type of epithelioid cell 1 case （1.4%） , 3 cases （4.2%） of mixed cell type. Immunohistoehemieal examination showed that 71 cases （98.6%） of CDll7-positive, 52 eases （72.2%） of CD34-positive, 22 cases （30.6%） of SMA-positive, 1 case （1.4%） of Desmin positive, 6 cases （8.3%） of S-100 positive. Conclusion GIST has many occurrence sites and complex mor- phological performance, combined with immunohistochemieal examination can help clinical diagnosis and identity.