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| 蜂斗菜不同极性部位抗过敏的实验研究 | |
| 引用本文： | 郑倩倩,孔培俊,吴喜民,李慧良,李医明. 蜂斗菜不同极性部位抗过敏的实验研究[J]. 上海中医药大学学报, 2011, 0(4): 79-82 |
| 作者姓名： | 郑倩倩 孔培俊 吴喜民 李慧良 李医明 |
| 作者单位： | 上海中医药大学中药学院;上海家化联合股份有限公司科研部; |
| 基金项目： | 上海市教委“东方学者”资助项目(2008); 上海中医药大学杏林团队资助项目 |
| 摘 要： | 目的:研究蜂斗菜抗过敏有效部位。方法:蜂斗菜95%乙醇提取物分别用石油醚、氯仿、正丁醇萃取,各部位均进行小鼠同种和异种被动皮肤过敏反应(PCA)实验、组胺致小鼠毛细血管通透性增高实验及2,4-二硝基氯苯(DNCB)致小鼠迟发型超敏反应(DTH)实验,从而确定蜂斗菜抗过敏有效部位。结果:与模型组比较,蜂斗菜氯仿提取部位在小鼠同种及异种被动皮肤过敏反应(PCA)模型、组胺致小鼠毛细血管通透性增高模型以及小鼠迟发型超敏反应(DTH)模型上均显示显著的抗过敏作用,差异有统计学意义(P<0.05)。结论:蜂斗菜氯仿提取部位有良好的抗Ⅰ型和Ⅳ型超敏反应作用。 |
| 关 键 词： | 蜂斗菜 有效部位 抗过敏 超敏反应 |
Experimental Study of Anti-allergy Effects of Bioactive Fraction of Petasites japonicus |
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| ZHENG Qian-qian KONG Pei-jun WU Xi-min LI Hui-liang LI Yi-ming .College of Chinese Pharmacy,Shanghai University of Traditional Chinese Medicine .Research , Development Department,Shanghai Jahwa United Co.Ltd.,Shanghai. Experimental Study of Anti-allergy Effects of Bioactive Fraction of Petasites japonicus[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2011, 0(4): 79-82 | |
| Authors: | ZHENG Qian-qian KONG Pei-jun WU Xi-min LI Hui-liang LI Yi-ming .College of Chinese Pharmacy Shanghai University of Traditional Chinese Medicine .Research & Development Department Shanghai Jahwa United Co.Ltd. Shanghai |
| Affiliation: | ZHENG Qian-qian1 KONG Pei-jun2 WU Xi-min1 LI Hui-liang2 LI Yi-ming1 1.College of Chinese Pharmacy,Shanghai University of Traditional Chinese Medicine 2.Research & Development Department,Shanghai Jahwa United Co.Ltd.,Shanghai |
| Abstract: | Objective: To study the anti-allergy bioactive fraction of Petasites japonicus.Methods: 95% ethanol extracts from Petasites japonicus were divided into petroleum ether,chloroform and n-butanol soluble parts separately.The anti-allergy bioactive effects of different parts were investigated in the mice of the model of the homogeneous and heterogeneous passive cutaneous allergic reaction(PCA),the model of capillary permeability increase caused by histamine and the model of delayed type hypersensitivity(DTH) in... |
| Keywords: | Petasites japonicus bioactive fraction of anti-allergy hypersensitivity |
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