| 葛根总黄酮对Lieber-Decarli酒精性肝损伤大鼠库普弗细胞活化信号通路的干预作用 |
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| 引用本文： | 崔团,彭景华,唐亚军,傅琪琳,许丽莉,冯琴,胡义扬.葛根总黄酮对Lieber-Decarli酒精性肝损伤大鼠库普弗细胞活化信号通路的干预作用[J].上海中医药大学学报,2011(3):71-75. |
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| 作者姓名： | 崔团 彭景华 唐亚军 傅琪琳 许丽莉 冯琴 胡义扬 |
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| 作者单位： | 上海中医药大学附属曙光医院肝病研究所肝肾疾病病证教育部重点研究室;上海市高校中医内科学E-研究院; |
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| 基金项目： | 上海市教育发展基金会“晨光计划”项目(2007CG56); 国家自然科学基金青年基金项目(81001575); 上海市教委项目(07cz024); 上海高校创新团队(第1期)建设项目 |
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| 摘 要： | 目的:观察葛根总黄酮对Lieber-Decarli酒精性肝损伤大鼠库普弗细胞活化信号通路的干预作用.方法:采用Lieber-Decarli酒精饮料饲养8周诱导的酒精性肝损伤模型,分设无酒精饮料组(C),酒精饮料组(M),酒精饮料+葛根总黄酮低剂量组(LT),酒精饮料+葛根总黄酮高剂量组(HT),每组10只大鼠,造模第3...
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| 关 键 词： | 酒精性肝损伤 库普弗细胞 葛根总黄酮 内毒素受体 肿瘤坏死因子 |
Effects of Pueraria Total Flavones on Activation Signal Pathway of Kupffer Cell in Alcoholic Hepatic Injury Rats Induced by Lieber-Decarli Liquid Diet |
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| CUI Tuan PENG Jing-hua TANG Ya-jun FU Qi-lin XU Li-li FENG Qin HU Yi-Yang.Effects of Pueraria Total Flavones on Activation Signal Pathway of Kupffer Cell in Alcoholic Hepatic Injury Rats Induced by Lieber-Decarli Liquid Diet[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2011(3):71-75. |
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| Authors: | CUI Tuan PENG Jing-hua TANG Ya-jun FU Qi-lin XU Li-li FENG Qin HU Yi-Yang |
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| Institution: | CUI Tuan1 PENG Jing-hua1 TANG Ya-jun1 FU Qi-lin1 XU Li-li1 FENG Qin1 HU Yi-Yang1,21.Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of TraditionalChinese Medicine,Key Laboratory of Liver and Kidney Diseases,Ministry of Education2.E-Institute of TCM Internal Medicine,Shanghai Municipal Education Commission |
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| Abstract: | Objective: To observe the effects of pueraria total flavones on activation signal pathway of Kupffer cell in alcoholic hepatic injury rats induced by Lieber-Decarli liquid diet.Methods: The alcoholic hepatic injury models were established by Lieber-Decarli liquid diet for 8 weeks.SD male rats were divided into control liquid diet group(C,n=10),ethanol liquid diet(M,n=10),pueraria total flavone low-dosage group(LT,n=10),pueraria total flavone high-dosage group(HT,n=10).Rats were administered with correspondi... |
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| Keywords: | Alcoholic liver injury Kupffer cell pueraria total flavones endotoxin receptor TNF-α |
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