| 健脾止痒颗粒对脾虚血燥型特应性皮炎患者Th1/Th2细胞因子谱的影响 |
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| 引用本文： | 金培志,杨瑛,赵跃凤,郭岱炯. 健脾止痒颗粒对脾虚血燥型特应性皮炎患者Th1/Th2细胞因子谱的影响[J]. 上海中医药大学学报, 2011, 0(4): 60-62 |
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| 作者姓名： | 金培志 杨瑛 赵跃凤 郭岱炯 |
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| 作者单位： | 广东省深圳市中医院皮肤科; |
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| 基金项目： | 广东省深圳市科技计划项目(200902135) |
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| 摘 要： | 目的:探讨健脾止痒颗粒对特应性皮炎(AD)患者Th1/Th2细胞因子谱的影响。方法:将60例特应性皮炎患者随机分为治疗组(30例)和对照组(30例),分别服用健脾止痒颗粒和氯雷他定片,疗程1个月。另设正常组(20例健康志愿者)作对照观察。采用Flowcytomix流式检测技术对各组血清Th1/Th2相关细胞因子进行芯片式集成测定。结果:与正常组比较,治疗前两组AD患者粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平显著降低(P<0.05);Th1型细胞因子IL-1α、IL-2、IFN-γ、TNF-α水平显著降低(P<0.05);Th2型细胞因子IL-4、IL-5、IL-6、IL-10水平显著升高(P<0.05)。治疗后两组GM-CSF、IL-1α、IL-2、TNF-α、IFN-γ水平较治疗前明显升高(P<0.05),且治疗组IFN-γ水平升高更显著(P<0.05);两组IL-4、IL-5、IL-6、IL-10水平较治疗前明显降低(P<0.05),且治疗组IL-4水平降低更显著(P<0.05)。结论:健脾止痒颗粒可通过调节Th1/Th2细胞因子网络的平衡发挥对AD的免疫治疗作用。
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| 关 键 词： | 特应性皮炎 细胞因子 健脾止痒颗粒 |
Influence of Jianpi Zhiyang Granule on Thl/Th2 Cytokines in Patients with Atopic Dermatitis of Spleen-deficiency and Blood-dryness Syndrome |
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| JIN Pei-zhi YANG Ying ZHAO Yue-feng GUO Dai-jiong. Influence of Jianpi Zhiyang Granule on Thl/Th2 Cytokines in Patients with Atopic Dermatitis of Spleen-deficiency and Blood-dryness Syndrome[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2011, 0(4): 60-62 |
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| Authors: | JIN Pei-zhi YANG Ying ZHAO Yue-feng GUO Dai-jiong |
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| Affiliation: | JIN Pei-zhi YANG Ying ZHAO Yue-feng GUO Dai-jiong Department of Dermatology,Shenzhen Hospital of Traditional Chinese Medicine,Guangdong |
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| Abstract: | Objective: To study the influence of Jianpi Zhiyang Granule,a herbal formula,on Thl/Th2 cytokines in patients with atopic dermatitis(AD).Methods: Sixty patients with AD of spleen-deficiency and blood-dryness syndrome were randomized into two groups: treatment group in which 30 cases were treated with Jianpi Zhiyang Granule and control group in which 30 cases were treated with loratadine tablet,with a course of one month.Besides 20 healthy persons were enrolled as control.The serum Th1/Th2 cytokines were det... |
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| Keywords: | Atopic dermatitis cytokine Jianpi Zhiyang Granule |
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