肝胰十二指肠联合移植一例报告并文献复习

目的 探讨肝胰十二指肠联合移植治疗终末期肝病合并1型糖尿病的疗效。方法 2003年9月对1例终末期肝病合并胰岛素依赖型糖尿病的患者行同期原位肝、异位胰十二指肠联合移植。结果 术后移植胰腺功能良好,完全脱离胰岛素治疗。术后1周发生移植肝急性排斥反应,经激素冲击治疗后逆转。患者已存活1年9个月,肝脏及胰腺功能均正常,一般情况良好。结论 肝胰十二指肠联合移植是治疗终末期肝病合并糖尿病的有效方法。

Simultaneous liver-pancreas-duodenum transplantation: one case report and review of the literature

Objective To investigate the effect of treatment on end-stage liver disease and type-I diabetes mellitus with simultaneous liver-pancreas-duodenum transplantation. Method In September 2003, one patient with chronic hepatitis B, liver cirrhosis, hepatic cellular cancer, and insulin-dependent diabetes received simultaneous orthotopic liver and heterotopic pancreas-duodenum transplantation. Liver and pancreas graft function was monitored after transplantation. Results The function of pancreas allograft was recovered immediately and the patient became insulin-independence postoperatively. The liver allograft was experienced an acute rejection episode and reversed by intravenous bolus methylprednisolone. The recipient was currently liver disease-free and insulin-free more than 21 months. Conclusions The simultaneous liver-pancreas-duodenum transplantation is an effective method in the treatment of end-stage liver disease and type-I diabetes mellitus.