| 古尼拟青霉胞外多糖的免疫抑制活性 |
| |
| 引用本文： | 肖建辉,方宁,肖瑜,祁莹,刘金伟,梁宗琦.古尼拟青霉胞外多糖的免疫抑制活性[J].中药材,2004,27(3):192-195. |
| |
| 作者姓名： | 肖建辉 方宁 肖瑜 祁莹 刘金伟 梁宗琦 |
| |
| 作者单位： | 1. 遵义医学院附属医院贵州省细胞工程重点实验室,遵义563003
2. 贵州大学真菌资源研究室,贵阳550025 |
| |
| 摘 要： | 目的:研究古尼拟青霉胞外多糖的生物活性.方法:分别采用MTT法、中性红比色法测定古尼拟青霉胞外多糖对小鼠脾淋巴细胞增殖、腹腔巨噬细胞(PMΦ)吞噬功能以及细胞毒T淋巴细胞(CTL)的杀伤活性的影响.结果:古尼拟青霉胞外多糖在10 μg/ml剂量时能明显抑制小鼠脾淋巴细胞增殖、腹腔巨噬细胞吞噬功能以及细胞毒T淋巴细胞的活性.结论:古尼拟青霉胞外多糖具有免疫抑制的生物活性,在免疫抑制类药物开发方面展现了良好的应用前景.
|
| 关 键 词： | 古尼拟青霉 胞外多糖 生物活性 免疫抑制 |
| 修稿时间： | 2003年10月28 |
Immunosuppressive Activity of Exopolysaccharide from Paecilomyces gunnii |
| |
| Xiao Jianhui,Fang Ning,Xiao Yu,Qi Ying,Liu Jinwei,Liang Zongqi.Immunosuppressive Activity of Exopolysaccharide from Paecilomyces gunnii[J].Jorunal of Chinese Medicinal Materials,2004,27(3):192-195. |
| |
| Authors: | Xiao Jianhui Fang Ning Xiao Yu Qi Ying Liu Jinwei Liang Zongqi |
| |
| Institution: | Key Lab. of Cell Engineering of Guizhou Province, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003. |
| |
| Abstract: | OBJECTIVE: To investigate bioactivities of Paecilomyces gunnii exopolysaccharide (PGEP). METHODS: The effects of PGEP on mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis and cytotoxin T lymphocytes (CTL) activity were studied by MTT method, neutral red colorimetry, respectively. RESULTS: In vitro, mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis of neutral red and CTL activity were significant suppressed by PGEP, especially in 10 microg/ml. CONCLUSION: PGEP had the immunosuppressive activities. |
| |
| Keywords: | Paecilomyces gunnii Exopolysaccharide Bioactivity Immunosuppressive activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
