Evaluation of the effect of terpenoid quinones on Trichophyton mentagrophytes by solution and vapor contact |
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| Authors: | Shigeharu Inouye Katsuhisa Uchida Toshio Takizawa Hideyo Yamaguchi Shigeru Abe |
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| Institution: | (1) Teikyo University Institute of Medical Mycology, 256 Otsuka, Hachioji, Tokyo 192-0395, Japan;(2) Teikyo Association of Medical Mycology, Tokyo, Japan;(3) Teikyo University Institute of Medical Mycology, Tokyo, Japan;(4) Teikyo University Institute of Medical Mycology, Teikyo Association of Medical Mycology, Tokyo, Japan;(5) Teikyo University Institute of Medical Mycology, Tokyo, Japan |
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| Abstract: | The antimicrobial activity against two bacterial strains and three fungi of five terpenoid quinones, three related quinones,
and a quinone-containing essential oil was investigated by broth dilution and by agar vapor and box vapor assays. All the
quinones, except for coenzyme Q10, exhibited their highest activity against Trichophyton mentagrophytes. Thymoquinone showed the most potent activity, not only by solution contact but also by vapor contact, with menadione the
next most potent. Alizarin showed high activity only by solution contact. The antibacterial activity was related to the orthoquinone
structure (1,2-chloranil and 1,2-naphthoquinone) and the antifungal activity was related to the paraquinone structure (chloranil,
ubiquinone 0, thymoquinone, and menadione). |
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| Keywords: | Terpenoid quinone Thymoquinone Alizarin Antibacterial activity Antifungal activity Trichophyton mentagrophytes |
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