可溶性细胞粘附分子1、促肾上腺皮质激素释放激素及白细胞介素6在妊娠高血压综合征发病中的作用

目的　研究可溶性细胞粘附分子 1(soluble intracellular adhesion m olecule- 1,s ICAM-1)、促肾上腺皮质激素释放激素 (cortictropin- releasing horm one,CRH)及白细胞介素 6 (interleukin-6 ,IL- 6 )在妊娠高血压综合征 (妊高征 )发病中的作用。　方法　测定 81例妊娠 2 6～ 37周孕妇血浆s ICAM- 1、CRH、IL- 6水平 ,其中 2 3例 ,为正常孕妇 (正常妊娠组 ) ;5 8例为妊高征孕妇 (妊高征组 ) :包括轻度 2 1例、中度 19例、重度 18例。用酶联免疫法测定 s ICAM- 1及 IL- 6 ,用放射免疫法测定 CRH。　结果　中、重度妊高征患者的血 s ICAM- 1、CRH、IL- 6水平均显著高于正常对照组 (P<0 .0 5 ) ,轻度妊高征患者与正常组相比虽无统计学差异但有升高的趋势。IL- 6水平与 CRH呈正相关 (r=0 .5 1,P<0 .0 5 )。　结论　妊高征患者血 s ICAM- 1升高表明内皮细胞损伤在妊高征的发病中起重要作用。CRH分泌的异常增加可能与内皮细胞的损伤有关 ,该作用可能是通过促进 IL- 6的分泌实现的

Role of Soluble Intracellular Adhesion Molecule-1, Co rticotropin-releasing Hormone and Interleukin-6 in the Pathogenesis of Pregnan cy-induced Hypertension

Objective To investigate the role of soluble intracellular adhesion molecule-1(sICAM-1), corticotropin-releasing hormone(CRH)and interleukin-6(IL-6) in the pathogenesis of pregnancy-induced hypertension (PIH). Methods Maternal plasma sICAM-1, CRH and IL-6 level were determined in 81women at 26~37 gestational weeks among which 23 were normal pregnant women and 58 with PIH. The later were grouped into 21 women with mild, 19 with moderate, 18 with severe PIH. sICAM-1 and IL-6 were measured by ELISA and CRH by RIA. Results The levels of plasma sICAM, CRH and IL-6 were significantly elevated in women with moderate and severe PIH compared with control subjects(P<0.05). The IL-6 levels were positively correlated with CRH (r=0.51, P<0.05). Conclusion Elevated levels of sICAM indicate that a primary endothelial cell dysfunction play an important role in the pathogenesis of PIH. Elevated CRH level may be associated with the endothelial cell injury by causing IL-6 levels increase.