Induction of HIV-1 Specific Mucosal Immune Responses by DNA Vaccination |
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| Authors: | Y. ASAKURA,J. HINKULA,A.-C. LEANDERSSON,J. FUKUSHIMA,K. OKUDA,& B. WAHREN |
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| Affiliation: | ;Microbiology and Tumor Biology Center, Karolinska Institute, Swedish Institute for Infectious Disease Control, Stockholm, Sweden and;Yokohama City University School of Medicine, Yokohama, Japan |
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| Abstract: | ![]()
DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization. |
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