| 托吡酯抗痫作用的动物实验研究 |
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| 引用本文： | 朱祖余,周俐,等.托吡酯抗痫作用的动物实验研究[J].赣南医学院学报,2000,20(4):312-315. |
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| 作者姓名： | 朱祖余 周俐 |
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| 作者单位： | 赣南医学院附属医院(朱祖余)，赣南医学院基础部!江西赣州341000(周俐，胡晓，周青) |
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| 摘 要： | 目的：通过动物实验比较托吡酯（妥泰）与传统抗痫药的抗痫作用。方法 比较观察三种剂量的托吡酯与1－2种传统抗痫药对最大电休克发作试验，戊四唑发作阈值试验，印防已毒素发作试验，士的宁发作试验的作用。结果：大中剂量的长吡酯对最大电休克发作试验、戊四唑发作阈值试验、印防已毒素发作试验有效，但效果不如传统药物。结论：托吡酯是一种作用广泛的抗痫新药，但作为单独用药或首选用药还需临床进一步论证。
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| 关 键 词： | 托吡酯 抗痫作用 动物实验 药理 |
The Study of Antiepileptic Effects of Topiramate by Animal Experiment |
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| ZHU Zu yu,et al.The Study of Antiepileptic Effects of Topiramate by Animal Experiment[J].Journal of Gannan Medical College,2000,20(4):312-315. |
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| Authors: | ZHU Zu yu |
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| Institution: | Affiliated Hospital of Gannan Medical College |
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| Abstract: | Objective:To compare the antiepileptic effects of Topiramate and traditional antiepileptic drugs by experiment with animals. Method Observe and compare Topiramate of three kinds of doses with 1-2kinds of traditional antiepileptic drugs and their effects on manimal eletroshock seizure test,Metrazol seizure threshold test , Picrotoxin seizure test and Strychine seizure test . Result largeand medium doses of Topiramate were effective , but not so effective as traditional antiepileptic drugs.Therefore, whether it can be used alone or as the first choice needs further clinical proof. |
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| Keywords: | Topiramate antiepileptic effects animal experiment |
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