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Application of Screening Methods,Shape Signatures and Engineered Biosensors in Early Drug Discovery Process
Authors:Izabela Hartman  Alison R. Gillies  Sonia Arora  Christina Andaya  Nitya Royapet  William J. Welsh  David W. Wood  Randy J. Zauhar
Affiliation:(1) Department of Chemistry & Biochemistry, University of the Sciences in Philadelphia, 600 S. 43rd Street, Philadelphia, Pennsylvania 19104, USA;(2) Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, USA;(3) Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS), New Brunswick, New Jersey, USA;(4) UMDNJ Informatics Institute, 675 Hoes Lane, Piscataway, New Jersey 08854, USA;(5) Mercer County Community College, 1200 Old Trenton Road, West Windsor, New Jersey 08550, USA;
Abstract:

Purpose  

In this study, two unreported estrogen antagonists were identified using a combination of computational screening and a simple bacterial estrogen sensor.
Keywords:
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