CD44v6、P27蛋白在乳腺癌组织中的表达及意义

目的 探讨乳腺癌中CD44v6、p27蛋白表达的意义。方法 应用免疫组化S-P法检测65例乳腺癌中CD44v6、p27蛋白表达。结果 65例乳腺癌中CD44v6、p27蛋白表达总阳性率分别为58.4％、38.4％。CD44v6蛋白阳性表达率与乳腺癌组织学类型、腋淋巴结转移呈正相关(P<0.05,P<0.01),与预后呈负相关(P<0.01),与组织学分级无明显相关性(P>0.05);p27蛋白阳性表达与乳腺癌组织学类型、组织学分级及腋淋巴结转移呈负相关(P<0.05),与预后呈正相关(P<0.05)。结论 CD44v6、p27蛋白表达与乳腺癌浸润、转移及预后显著相关,检测乳腺癌中CD44v6、p27蛋白表达水平,对判断乳腺癌恶性程度、复发转移潜能,评估患者预后及术后选择合理治疗方案有一定参考价值。

Expressions of CD44v6 and p27 proteins in breast carcinoma and their signifcances

Objective To explore the expression and significance of CD44v6 and p27 protions in breast carcinoma.Method The expressions of CD44v6 and p27 proteins in 65 cases of breast carcinoma were detected with S-P immunohistochemical method. Results The expression rates of CD44v6 and p27 protein were 58.4% and 38.4% ,respectively.The expression of CD44v6 protein was positively correlated with histological types and lymph node metastasis of breast carcinoma( P < 0.05, P < 0.01), and negatively correlated with prognosis ( P < 0.01) . There was no evident correlation between CD44v6 expression and histological differentiation ( P > 0.05) . The expression of p27 protein was negatively correlated with histological type,differentiation and lymph node metastasis( P < 0.05),but was positively correlated with prognosis(P < 0.05). Conclusion The expressions of CD44v6 and p27 proteins are correlated with development, metastasis and prognosis of breast carcinoma. Detecting the expression levels of CD44v6 and p27 proteins in breast carcinoma has important reference values in judging infiltration, evaluating prognosis and selecting rational therapeutic method after surgery.