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| 苦参碱类生物碱抗肉瘤药理作用的研究进展 | |
| 引用本文： | 张明发,沈雅琴. 苦参碱类生物碱抗肉瘤药理作用的研究进展[J]. 现代药物与临床, 2018, 41(11): 2117-2122 |
| 作者姓名： | 张明发 沈雅琴 |
| 作者单位： | 上海美优制药有限公司, 上海 201204,上海美优制药有限公司, 上海 201204 |
| 摘 要： | 苦参碱类生物碱（苦参碱、氧化苦参碱、槐果碱、槐定碱）可通过下调肉瘤细胞表达各种细胞生长因子（如血管内皮生长因子等），阻滞血管新生，间接抑制肉瘤生长；还能直接抑制肉瘤细胞增殖并促进其凋亡，产生抗肉瘤作用。苦参碱类生物碱还可通过下调P-糖蛋白、肺耐药蛋白、DNA拓扑异构酶的过度表达，解除肉瘤细胞的多药耐药性，提高其对化疗药的敏感性。 |
| 关 键 词： | 苦参碱类生物碱 苦参碱 氧化苦参碱 槐果碱 槐定碱 肉瘤 |
| 收稿时间： | 2018-07-09 |
Research advances on anti-sarcoma effects of matrine-type alkaloids |
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| ZHANG Mingfa and SHEN Yaqin. Research advances on anti-sarcoma effects of matrine-type alkaloids[J]. Drugs & Clinic, 2018, 41(11): 2117-2122 | |
| Authors: | ZHANG Mingfa and SHEN Yaqin |
| Affiliation: | Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201204, China and Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201204, China |
| Abstract: | Matrine-type alkaloids (matrine, oxymatrine, sophocarpine, sophoridine) can indirectly inhibit sarcoma growth and angiogenesis by down-regulating the expression of cellular growth factors (eg. vascular endothelial growth factor) of sarcoma cells. Also, matrine-type alkaloids can directly inhibit proliferation and increase apoptosis of sarcoma cells to exert anti-sarcoma effects. By down-regulating the overexpression of P-glycoprotein, lung resistance protein, and DNA topoisomerase, matrine-type alkaloids relieve multi-drug resistance of sarcoma cells to enhance its sensitivity to chemotherapeutics. |
| Keywords: | matrine-type alkaloids matrine oxymatrine sophocarpine sophoridine sarcoma |
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