血清斯钙素⁃1在稳定期慢性阻塞性肺病中的表达及意义

目的：探讨斯钙素?1（stanniocalcin?1，STC1）在稳定期慢性阻塞性肺病（chronic obstructive pulmonary disease，COPD）患者血清中的表达及意义。方法：收集55例稳定期COPD患者，根据肺功能和问卷评分进行相应分组，且以24例健康者作为对照。采用酶联免疫吸附法（ELISA）测定各研究对象的血清斯钙素?1表达情况，进行相关分析。结果：①与健康对照组相比，稳定期COPD患者血清斯钙素?1表达水平明显降低（P < 0.05）。②血清斯钙素?1在初筛COPD上具有一定价值（P=0.025，AUC=0.659），最佳阈值为1 350 pg/mL（敏感度81.82%；特异度50.00%）。③血清斯钙素?1与稳定期COPD患者病情严重程度［包括GOLD分级、慢阻肺评估测试（COPD assessment test，CAT）评分、ABCD分组、肺功能］无明显相关性。结论：血清斯钙素?1在COPD中显著降低，可能对于COPD的诊治具有一定临床意义。

The role of serum stanniocalcin-1 in chronic obstructive pulmonary disease

Objective: To investigate the serum level of stanniocalcin-1 (STC1) in patients with stable chronic obstructive pulmonary diseases (COPD) and to explore the relationship between STC1 and severity of the disease. Method: 55 patients with definite stable COPD and 24 healthy controls were enrolled in this study. Serum STC1 was measured by Enzyme-linked immunosorbent assay (ELISA), and the correlation between STC1 and COPD was analyzed. Results:1) Serum STC1 levels were significantly lower in patients with COPD than healthy controls (p&amp;amp;amp;lt;0.05). 2) The receiver-operating characteristic (ROC) curve of serum SCT1 was used for threshold identification (area=0.6591, p=0.0252), the optimal cut-off point of serum STC1 was 1350 pg/ml (sensitivity 81.82%, specificity 50%, respectively). 3) Poor association of serum STC1 levels with stable COPD was found, including the GOLD classification, COPD assessment test (CAT) scores and lung functions. Conclusion: Serum STC1 levels were significantly decreased in COPD patients while it is poorly correlated with disease severity. STC1 might have clinical application in stable COPD.