相位值在鉴别原发性中枢神经系统淋巴瘤与胶质母细胞瘤中的作用

目的 探讨相位值在鉴别原发性中枢神经系统淋巴瘤（PCNSL）与胶质母细胞瘤（GBM）中的作用。方法 选择2009年1月至2017年12月在中国人民解放军第105医院确诊的30例PCNSL与26例GBM患者，回顾性分析患者的影像资料。所有的患者均行常规MRI及SWI，在SWI序列相位图上测量PCNSL和GBM的肿瘤实性、瘤周2 cm内脑组织及对侧正常脑组织等面积的感兴趣区域（ROI），测量ROI的相位值，比较分析患者的相位值。结果 GBM患者肿瘤实质、瘤周2 cm脑组织、对侧正常脑组织的相位值分别为-10.63±9.27、-3.94±8.55、-4.85±5.16。PCNSL患者肿瘤实质、瘤周2 cm脑组织、对侧正常脑组织的相位值分别为1.12±10.47、-5.87±18.00、-5.46±4.90。GBM瘤周2 cm脑组织、对侧正常脑组织的相位值均高于PCNSL，差异无统计学意义（P>0.05）。GBM肿瘤实质相位值低于PCNSL，差异有统计学意义（P<0.05）。结论 肿瘤实质相位值能够有效的鉴别GBM和PCNSL。

Role of phase values indiagnosisof primary central nervous system lymphoma and glioblastoma

Objective To explore the role of phase value in the differential diagnosis of primary central nervous system lymphoma(PCNSL) and glioblastoma(GBM).Methods The clinical data of30 caseswith PCNSL and 26 cases with GBM pathologically confirmed by magnetic resonance imaging(MRI) and susceptibility weighted imaging(SWI) from Jan 2009 to Dec 2017 inthe 105th Hospital of Chinese People''s Liberation Army were retrospectively analysed.The phase values of region of interest(ROI) from the tumor parenchyma,tumor tissue within 2 cm of peritumoral area and contralateral normal brain tissue were measured directly through phase image of SWI. Also whether there was difference between groups in the phase values wasevaluated.Results The phase value of GBM parenchyma,tumor tissue within 2 cm of peritumoral area and contralateral normal brain tissue was -10.63±9.27,-3.94±8.55, -4.85±5.16, respectively. The phase value of PCNSL parenchyma, tumor tissue within 2 cm of peritumoral area and contralateral normal brain tissue was 1.12±10.47, -5.87±18.00, -5.46±4.90, respectively. There wasno significant difference in phase values from tumor tissue within 2 cm of peritumoral area and contralateral normal brain tissue between PCNSL and GBM(P>0.05). The phase value of tumor parenchyma from GBM was significantly lower thanthat from the PCNSL(P<0.05).Conclusion The phase value of tumor parenchyma can effectively identify GBM and PCNSL.