低出生体质量儿坏死性小肠结肠炎的影响因素及手术疗效分析

目的 探讨低出生体质量儿坏死性小肠结肠炎(NEC)的影响因素、手术疗效与预后。 方法 以2006年1月至2015年12月收治的146例低出生体质量NEC患儿为病例组,另采用随机数字表法选取同期在新生儿重症监护室(NICU) 住院治疗的146例非NEC低出生体质量儿为对照组。分析两组患儿的临床资料,采用单因素和多因素分析探讨NEC的影响因素,并分析NEC患儿中手术组与保守治疗组疗效的差异。 结果 多因素logistic回归分析显示,母乳喂养与喂服益生菌为NEC的保护性因素,先天性心脏病、败血症与输血是NEC的危险因素。手术组的好转率(95.45%)明显高于保守治疗组(85.00%)(P<0.05)。 结论 低出生体质量儿NEC的发病受多种因素影响,应针对其影响因素进行综合干预。适合的手术疗法能提高疗效,改善患儿的预后。

Determinants and surgery effects of low birth weight neonates with necrotizing enterocolitis

Objective To probe the determinants,surgery effects and prognosis of low birth weight neonates with necrotizing enterocolitis (NEC). Methods A total of 146 low birth weight neonates with necrotizing enterocolitis from January 2006 to December 2015 were chosen as case group,and 146 low birth weight neonates without necrotizing enterocolitis from neonatal intensive care unit (NICU) in the same period were selected according to the random number table method as control group.The clinical data of the two groups were retrospectively collected and the determinants were probed by single-factor and multi-factor analysis.The differences between surgery NEC group and conservative treatment NEC group was analyzed. Results Multivariate logistic regression analysis showed that breastfeeding and feeding probiotics were the protective factors of NEC,congenital heart disease,sepsis and blood transfusion were risk factors for NEC.The improvement rate of the operation group (95.45%) was significantly higher than that of the conservative treatment group (85.00%) (P<0.05). Conclusions The incidence of NEC in low birth weight neonates was influenced by many factors,and comprehensive intervention should be carried out for its influencing factors.Appropriate surgery treatment can improve curative effects and prognosis of child.