| 基于超分子“印迹模板”特征的中药制剂体系可调配性研究 |
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| 引用本文： | 李文姣,刘文龙,杨岩涛,周逸群,陈思阳,王韧,樊启猛,刘惠,贺福元,肖美凤.基于超分子“印迹模板”特征的中药制剂体系可调配性研究[J].中草药,2018,49(24):5733-5739. |
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| 作者姓名： | 李文姣 刘文龙 杨岩涛 周逸群 陈思阳 王韧 樊启猛 刘惠 贺福元 肖美凤 |
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| 作者单位： | 湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学 中医药超分子机理与数理特征化实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学 中医药超分子机理与数理特征化实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学 中医药超分子机理与数理特征化实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学 中医药超分子机理与数理特征化实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学 中医药超分子机理与数理特征化实验室, 湖南 长沙 410208 |
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| 基金项目： | 国家自然科学基金资助项目（81073142）；国家自然科学基金资助项目（81173558）；国家自然科学基金资助项目（81270055）；国家博士点基金项目（20124323110002）；湖南药学国内一流学科（培育）开放基金项目 |
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| 摘 要： | 运用超分子化学理论,在前期诠释中医药基础理论,提出"气析"作用理论的基础上,进一步分析中药制剂固有的超分子"印迹模板"群聚集体的特点,结合中药制剂历史发展轨迹,从中药制剂特点、发展现状、亟需解决的关键问题及对策等方面进行探讨。中药制剂可在超分子化的中医药基础理论指导下,建立以物质结构与人体超分子"印迹模板"及"气析"作用明确的"药素"成分群为原料,单用确定与合用可调配的整体相统一的中药复方制剂体系。
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| 关 键 词： | 中药制剂 药素 超分子 确定性 调配性 成分群 |
| 收稿时间： | 2018/10/11 0:00:00 |
Study on dispensability of Chinese materia medica pharmaceutical system based on supramolecular imprinting template characteristics |
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| LI Wen-jiao,LIU Wen-long,YANG Yan-tao,ZHOU Yi-qun,CHEN Si-yang,WANG Ren,FAN Qi-meng,LIU Hui,HE Fu-yuan and XIAO Mei-feng.Study on dispensability of Chinese materia medica pharmaceutical system based on supramolecular imprinting template characteristics[J].Chinese Traditional and Herbal Drugs,2018,49(24):5733-5739. |
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| Authors: | LI Wen-jiao LIU Wen-long YANG Yan-tao ZHOU Yi-qun CHEN Si-yang WANG Ren FAN Qi-meng LIU Hui HE Fu-yuan and XIAO Mei-feng |
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| Institution: | College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China,College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China and College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China |
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| Abstract: | According to foundations of previous explications of basic theories of the Chinese materia medica (CMM) with supramolecular chemistry as "Qi chromatograpy", we further analyzed the intrinsic characteristics of supramolecular "imprinting templates" aggregation, and then discussed on aspects of the development direction, characteristics, key issues to be solved as well as countermeasures by combining the historical development of CMM preparations. Under the guidance of supramolecular theories of CMM, CMM preparations can establish the system that are originated form the materials which are of "medical elements" direction with explicit reaction on supramolecular "imprinting templates" of human body and carrying out "Qi chromatography", and implementing the integration of determinacy for single administration and compatibility for combination applications. |
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| Keywords: | pharmaceutics of CMM medical element supramolecules determinacy compatibility ingredient groups |
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