山玉兰叶化学成分研究

目的对山玉兰Magnolia delavayi叶的化学成分进行研究。方法采用MCI、硅胶、Sephadex LH-20、HPLC等多种色谱技术进行分离纯化,根据波谱数据鉴定化合物的结构。结果从山玉兰叶95%乙醇提取物中分离得到14个化合物,分别鉴定为(2E)-3,7,11-trimethyl-2,10-dodecadien-l,6,7-triol(1)、(2E,6E)-3,7,11-trimethyl-2,6-dodecadien-l,10,11-triol(2)、黑麦草内酯(3)、松脂醇(4)、丁香脂素(5)、梣皮树脂醇(6)、桉脂素(7)、连翘脂素(8)、松柏醛(9)、3,4,5-三甲氧基肉桂醇(10)、3-吲哚甲醛(11)、3-吲哚乙醇(12)、3,4-二甲氧基苯甲酸(13)、3,4-二甲氧基苯酚(14)。结论所有化合物均为首次从该植物中分离得到,并且首次报道化合物1的1H-和13C-NMR数据。

Chemical constituents from leaves of Magnolia delavayi

Objective To study the chemical constituents from the leaves of Magnolia delavayi. Methods The chemical constituents were isolated and purified by column chromatography on silica gel, Sephadex LH-20, MCI, and HPLC. Their structures were identified based on spectroscopic data. Results Fourteen compounds were isolated from 95% ethanol aqueous extract of M. delavayi and the structures were identified as (2E)-3,7,11-trimethyl-2,10-dodecadien-l,6,7-triol (1), (2E,6E)-3,7,11-trimethyl-2,6-dodecadien-l,10,11- triol (2), loliolide (3), pinoresinol (4), syringaresinol (5), medioresinol (6), eudesmin (7), phillygenin (8), coniferaldehyde (9), 3,4,5-trimethoxycinnamyl alcohol (10), indole-3-carboxaldehyde (11), indole-3-ethanol (12), 3,4-dimethoxy-benzoic acid (13), and 3,4-dimethoxyphenol (14). Conclusion All compounds are isolated from this plant for the first time. In addition, the ¹H- and ¹³C-NMR spectroscopic data are reported for the first time in the current study.