IL-17 and related cytokines involved in systemic sclerosis: Perspectives |
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| Authors: | Rafaela Silva Guimarães Gonçalves Michelly C. Pereira Andréa Tavares Dantas Anderson Rodrigues de Almeida Claudia Diniz Lopes Marques |
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| Affiliation: | 1. Hospital das Clínicas de Pernambuco, Universidade Federal de Pernambuco, Recife, Brazil;2. Laboratório de Imunomodula??o e Novas Abordagens Terapêuticas Suely Galdino, Universidade Federal de Pernambuco, Recife, Brazil;3. Laboratório de Imunomodula??o e Novas Abordagens Terapêuticas Suely Galdino, Universidade Federal de Pernambuco, Recife, Brazil |
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| Abstract: | ![]()
Systemic sclerosis (SSc) is a multisystemic, complex, and rare disease of connective tissue, with high morbidity and mortality, and without specific treatment. The disease is characterized by three main principles: vascular disease, autoantibody production and inflammation, and fibrosis. Since it is well defined that SSc is characterized by elevated production of TGF-β, IL-6, and IL-1, all of them cytokines related to Th17 differentiation, the hypothesis is that this disease may be strongly related to a polarization of the immune response towards the Th17 pathway. Considering the importance of a better understanding of the pathophysiology of Th17 pathway in SSc, this article aims to propose an update for a better understanding of current knowledge on main cytokines secreted by the Th17 cells (IL-17?A, IL-21, and IL-22) and the future prospects in the current disease. |
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| Keywords: | CD4(+) T cells fibroblasts Th17 cells fibrosis |
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