血清高分子量脂联素水平与动脉硬化的相关性

目的：探讨血清高分子量脂联素水平与动脉硬化的关系。方法：选择2011年1月至2011年12月到湘雅二医院进行健康体检的居家中老年人87例，收集其临床资料。以颈-股脉搏波传导速度（cf-PWV ）＝9 m/s为界分为：A组（cf-PWV＜9 m/s）21例， B组（cf-PWV≥9 m/s）66例，检测两组患者血压、血脂、血糖等代谢指标并进行比较。结果：与A组比较，B组血压明显升高，血低密度脂蛋白胆固醇、甘油三酯、总胆固醇水平显著升高，高密度脂蛋白胆固醇、血清总脂联素及高分子量脂联素水平显著降低（ P＜0.05或＜0.01）。多元回归分析显示血清高分子量脂联素（B＝-4.469， P＝0.011）、总脂联素（（B＝-3.96， P＝0.012）、高密度脂蛋白胆固醇（B＝-2.077， P＝0.015）水平和收缩压（B＝0.045， P＝0.045）是cf-PWV的独立预测因子。结论：血清高分子量脂联素和总脂联素水平可能是动脉硬化保护因素，其预测动脉硬化发生发展的作用值得进一步深入研究。

Correlation between serum high molecular weight adiponectin level and arteriosclerosis

Objective：To explore the correlation between serum level of high molecular weight adiponectin （HMW-ADPN） and arteriosclerosis .Methods ：Clinical data of 87 middle-aged and aged people living in home ,who under-went health examinations in Xiangya second hospital from Jan 2011 to Dec 2011 ,were collected .According to ca-rotid-femoral pulse wave velocity （cf-PWV） =9 m/s ,they were divided into group A （cf-PWV〈9 m/s ,n=21） and group B （cf-PWV≥9 m/s ,n=66） .Blood pressure ,blood lipid ,blood glucose etc .were measured and com-pared between two groups .Results：Compared with group A ,there were significant rise in blood pressure ,levels of low density lipoprotein cholesterol ,triglyceride and total cholesterol ,and significant reduction in levels of high den-sity lipoprotein cholesterol （HDL-C） ,serum total ADPN and HMW-ADPN in group B , P〈0.05 or 〈0.01. Multi-ple regression analysis indicated that serum HMW-ADPN （B= -4.469 , P=0.011） ,total ADPN （（B= -3.965 , P=0.012） ,HDL-C （B= -2.077 , P=0.015） and systolic blood pressure levels （B=0.045 , P=0.045） were inde-pendent predictors of cf-PWV .Conclusion：Serum high molecular weight adiponectin and total adiponectin levels may be protective factors against arteriosclerosis .Its role in predicting occurrence and development of arteriosclero-sis is worthy of further study .