| 季节性流感疫苗对严重急性呼吸道感染的保护效果分析 |
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| 引用本文： | 张代涛,初艳慧,李洪军,赵小娟,刘重程,周琳,宋晓旭,陈永亮,韩江涛,梁金博,王全意,黎新宇.季节性流感疫苗对严重急性呼吸道感染的保护效果分析[J].国际病毒学杂志,2019,26(2):77-81. |
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| 作者姓名： | 张代涛 初艳慧 李洪军 赵小娟 刘重程 周琳 宋晓旭 陈永亮 韩江涛 梁金博 王全意 黎新宇 |
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| 作者单位： | 北京市疾病预防控制中心北京市预防医学研究中心传染病地方病控制所 100013;北京市西城区疾病预防控制中心传染病地方病预防控制科 100120;北京市通州区疾病预防控制中心传染病与地方病控制科 101199;北京市怀柔区疾病预防控制中心传染病地方病防制科 101400;北京市昌平区疾病预防控制中心传染病地方病控制科 102200;北京市石景山区疾病预防控制中心流行病科 100043;北京市房山区疾病预防控制中心传染病与地方病控制科 102488;北京市密云区疾病预防控制中心疾病控制科 101500;北京市大兴区疾病预防控制中心传染病地方病防制科 102600;北京市海淀区疾病预防控制中心传染病与地方病控制科 100094 |
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| 基金项目： | 首都卫生发展科研专项项目(2018-1-1012);北京市科技计划课题(D141100003114002)。 |
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| 摘 要： | 目的估算北京市2016—2017年季节性流感疫苗接种对预防流感引起的严重急性呼吸道感染(severeacuterespiratoryinfection,SARI)的效果。方法通过SARI病例监测收集数据,应用病例对照设计,计算流感阳性与阴性病例中疫苗接种的比值比(oddsratio,OR)。结果2016—2017年季节性流感疫苗对于预防流感相关SARI的保护效果为45.1%(95%CI:6.7%~67.7%),对甲型H1N1流感和甲型H3N2亚型流感的保护效果分别为71.8%(95%CI:-20.1%~93.4%)和38.0%(95%CI:-10.7%~65.3%),对仅本季接种者的保护效果为60.2%(95%CI:-35.8%~88.4%)。结论2016—2017年季节性流感疫苗接种对预防流感引起的SARI有较好的效果,建议SARI易感人群每年接种流感疫苗。
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| 关 键 词： | 流感 疫苗 保护效果 |
Effectiveness of seasonal influenza vaccine against severe acute respiratory infections |
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| Zhang Daitao,Chu Yanhui,Li Hongjun,Zhao Xiaojuan,Liu Zhongcheng,Zhou Lin,Song Xiaoxu,Chen Yongliang,Han Jiangtao,Liang Jinbo,Wang Quanyi,Li Xinyu.Effectiveness of seasonal influenza vaccine against severe acute respiratory infections[J].International Journal of Virology,2019,26(2):77-81. |
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| Authors: | Zhang Daitao Chu Yanhui Li Hongjun Zhao Xiaojuan Liu Zhongcheng Zhou Lin Song Xiaoxu Chen Yongliang Han Jiangtao Liang Jinbo Wang Quanyi Li Xinyu |
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| Institution: | (Institute for Infectious Disease and Endemic Disease Control, Beijing Municipal Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China;Department for Infectious Disease and Endemic Disease Control, Haidian District Center for Disease Prevention and Control, Beijing 100094, China;Department for Infectious Disease and Endemic Disease Control, Xicheng District Center for Disease Prevention and Control, Beijing 100120, China;Department for Infectious Disease and Endemic Disease Control, Tongzhou District Center for Disease Prevention and Control, Beijing 101199, China;Department for Infectious Disease and Endemic Disease Control, Huairou District Center for Disease Prevention and Control, Beijing 101400, China;Department for Infectious Disease and Endemic Disease Control, Changping District Center for Disease Prevention and Control, Beijing 102200, China;Department of Epidemiology, Shijingshan District Center for Disease Prevention and Control, Beijing 100043, China;Department for Infectious Disease and Endemic Disease Control, Fangshan District Center for Disease Prevention and Control, Beijing 102488, China;Department for Disease Control, Miyun District Center for Disease Prevention and Control, Beijing 101500, China;Department for Infectious Disease and Endemic Disease Control, Daxing District Center for Disease Prevention and Control, Beijing 102600, China) |
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| Abstract: | Objective To estimate the vaccine effectiveness (VE) in preventing influenza associated severe acute respiratory infection (SARI) in 2016-2017 influenza season. Methods Data were collected from SARI surveillance. The case control study design was applied to calculate odds ratios (ORs) of vaccination among influenza positive and negative cases. Results During 2016-2017 influenza season, overall adjusted VE against influenza associated SARI was 45.1%(95%CI: 6.7 - 67.7). The VE against influenza A(H1N1) pdm09 was 71.8%(95%CI:-20.1 - 93.4%) and the VE against influenza A(H3N2) was 38.0%(95%CI:-10.7 - 65.3). For patients vaccinated only in the current season, the VE was 60.2%(95%CI:-35.8 - 88.4). Conclusions The seasonal influenza vaccine of 2016-2017 influenza season showed good vaccine effectiveness against influenza associated SARI. It is recommended that vunerable population of SARI should receive influenza vaccination every year. |
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| Keywords: | Influenza Vaccine Vaccine effectiveness |
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