Peaks and tails: Evaluation of irregularities in capillary serum protein electrophoresis |
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| Affiliation: | 1. Laboratory Medicine, Basel University Hospital, Petersgraben 4, Basel, CH-4031, Switzerland;2. Medica (Medizinische Laboratorien Dr. F. Kaeppeli AG), Zürich, Switzerland;1. Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Ontario, University of Toronto, Ontario, Canada;2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada;1. Department of Biochemistry and Pharmaco-Toxicology, University Hospital of Brest, Brest, France;2. Univ Brest, LIEN, F-29200 Brest, France;1. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada;2. DynaLIFE Medical Laboratories, Edmonton, Alberta T5J 5E2, Canada;1. Department of Biochemistry and Pharmaco-Toxicology, University Hospital of Brest, Brest, France;2. Univ Brest, LIEN, F-29200 Brest, France;1. SC Analisi Chimico Cliniche, Ospedale di Desio, Via Mazzini 1, 20832 Desio, Italy;2. Dipartimento Medicina-Chirurgia, Università Milano Bicocca, Via Cadore 48, 20900 Monza, Italy;3. Genetics Unit, ASST Lariana, via Ravona 20, 22020 San Fermo della Battaglia, Como, Italy;1. Department of Pathology, Brigham and Women''s Hospital, Boston, MA, United States;2. Dana-Farber Cancer Institute, Boston, MA, United States;3. Harvard Medical School, Boston, MA, United States |
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| Abstract: | The increased analytical sensitivity of capillary electrophoresis detects additional irregularities that are suspicious for a monoclonal component. This is most noticeable in the beta-1-, beta-2- and gamma-globulin fractions. The causes of non-monoclonal irregularities are manifold, but are rarely reported back to the ordering physician. This article reviews the basic concepts to correctly identify irregularities, monoclonal and oligoclonal peaks by capillary electrophoresis. It then focuses on detecting and reporting typical non-monoclonal irregularities according to their electrophoresis fractions as well as their possible clinical implications. |
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