红蓝光联合治疗对寻常痤疮患者血清IL-1、IL-6、IL-8水平的影响

目的：探讨红蓝光照射对寻常痤疮患者外周血IL-1、IL-6、IL-8表达的影响及其作用机制。方法：95例寻常痤疮患者随机分为实验组53例和对照组42例，实验组采用红蓝光联合异维A酸红霉素凝胶治疗，对照组采用异维A酸红霉素凝胶治疗，另选择24例健康体检者作为健康组，采用酶联免疫吸附法（ELISA）测定寻常痤疮患者治疗前、后和健康体检者外周血中IL-1、IL-6、IL-8水平。结果：寻常痤疮患者血清IL-1、IL-6、IL-8水平高于健康组（P〈0．01），治疗后实验组IL-1、IL-6、IL-8水平较治疗前明显降低，差异有统计学意义（P〈0．01），显著低于对照组（P〈0．05）。结论：红蓝光治疗寻常痤疮患者抑制了IL-1、IL-6、IL-8的表达，从而达到治疗作用。

Effect of Combined Red-Blue Light on IL-I and IL-6,1L-8 in serum expression of acne vulgaris patients

Objective To explore effect of Red-Blue Light on IL-I,IL-6,1L-8 expression of Acne vulgaris patients. Methods 95 patients with Ache vulgaris were devided randomly divided into 2groups,53 cases as experimental group were treated by Red-Blue Light combined with Isotrefinoin Erythromycin Gel and 42 cases as control group were treated by Isotrefinoin Erythromycin Gel. 24 healthy subjects served as normal controls.lL-l,lL-6,1L-8 level was determined by radioimmunity assay before and after the ciinical therapy. Results IL-I,IL-6,1L-8 in the patients with Ache vulgaris were significantly lower than that in healthy subjects （P〈0.01）.There was significant difference in IL-I,IL-6,1L-8 between Acne vulgaris patients and healthy persons before treatment. There was significant difference after treatment （P〈0.01）,and was higher than that in control group （P〈0.05）. Conclusion Red-Blue Light therapy in patients with Acne vulgaris inhibited IL-1,1L-6,1L-8 expression, so as to achieve a therapeutic effect.