| MicroRNA参与的调控网络 |
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| 引用本文： | 熊霞辉,陈梅红. MicroRNA参与的调控网络[J]. 医学分子生物学杂志, 2007, 4(4): 367-370 |
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| 作者姓名： | 熊霞辉 陈梅红 |
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| 作者单位： | 中国医学科学院基础医学研究所,中国协和医科大学基础医学院,医学分子生物学国家重点实验室,北京市,100005;中国医学科学院基础医学研究所,中国协和医科大学基础医学院,医学分子生物学国家重点实验室,北京市,100005 |
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| 摘 要： | 成熟的microRNA(miRNA)是一类长约18～24个核苷酸、内源性非编码小RNA分子,它在体内下调靶基因的表达。迄今在不同物种中已发现的miRNA达上千种。miRNA的发现为基因表达调控研究打开了新的窗口。目前研究者不仅关注miRNA在发育、分化、生长和代谢等诸多生物过程中的作用,而且开始进一步探寻其发挥作用的分子机理,以期重新描绘基因表达调控网络图。文章综述了miRNA对其靶基因的调控特点,介绍了miRNA自身调控研究的最新进展,从而有助于理解miRNA参与的基因表达调控网络的复杂性。
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| 关 键 词： | microRNA 调控 |
| 修稿时间： | 2007-04-24 |
MicroRNA-Involved Regulatory Network |
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| XIONG Xiahui,CHEN Meihong. MicroRNA-Involved Regulatory Network[J]. Journal of Medical Molecular Biology, 2007, 4(4): 367-370 |
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| Authors: | XIONG Xiahui CHEN Meihong |
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| Abstract: | Mature microRNAs(miRNAs)are endogenous small non-coding RNAs of about 18-24 nucleotides in length that negatively regulate target gene expression in vivo.Thousands of miRNAs have been discovered in a variety of organisms.The discovery of miRNAs opened a new window for study of regulation of gene expression.Researchers nowadays are not only interested in the roles of miRNAs in many biological processes such as development,differentiation,growth and metabolism,but also in the molecular mechanisms underlying these roles.This article reviews miRNAs-regulation of their target genes and advances in the self-regualtion of miRNAs. |
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| Keywords: | microRNA regulation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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