幼年类风湿关节炎免疫指标检测及临床意义

目的 探讨幼年类风湿关节炎(JRA)息儿T细胞亚群、免疫球蛋白(Ig)和红细胞沉降率(ESR)、C反应蛋白(CRP)联合检测的临床价值.方法 对40例确诊JRA患儿采用流式细胞术测定外周血T淋巴细胞亚群(CD3+、CD4+、CD16+、CD16+CD56+),采用速率散射比浊法检测Ig、CRP,ESR采用魏氏法,设正常对照组40例.结果 T细胞亚群CD3+、CD8+、CD16+CD56+与对照组比较明显降低,CD4+与对照组比较明显升高(均P<0.05),IgG、IgA、IgM、ESR和CRP均高于正常对照组(均P<0.05).结论 JRA患儿存在炎性反应,疾病活动时伴有细胞免疫、体液免疫两种免疫功能紊乱.

The detection of immune signs and their clinical significance in patients with JRA

Objective To explore the clinical value of detecting T cell subsets,immunoglobulin(Ig) ,erythro-cyte sedimentation rate(ESR),C-reactive protein(CRP) in patients with juvenile rheumatoid arthritis(JRA). Meth-ods T cell subsets(CD3+ , CD4+ , CD8+ , CD16+CD56+) was detected with flow cytometer, Ig, CRP with rate nephelome-try,ESR with Westergren's method in 40 cases of JRA,and other 40 normal children were served as normal control group. Results The level of CD3+ ,CD8+ ,CD16+CD56+ in the JRA group were lower,but CD4+ was higher than those in normal control group(P< 0.05 all) ;the level of IgA, IgG, IgM, ESR, CRP in the JRA group were all higher than those in the normal control group( P < 0.05 ). Conclusion There is an inflammation in patients with JRA, and when disease activity there is an immunological aberrance with cellular and humoral immunization.