Diffusion-weighted MRI in cervical cancer |
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| Authors: | Patrick Z. McVeigh Aejaz M. Syed Michael Milosevic Anthony Fyles Masoom A. Haider |
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| Affiliation: | (1) Department of Medical Imaging, University of Toronto, University Health Network, Princess Margaret Hospital, 610 University Ave, Toronto, ON, M5G 2M9, Canada;(2) Department of Radiology, The Queen Elizabeth Hospital, Gayton Road, King’s Lynn, PE30 4ET, UK;(3) Department of Radiation Oncology, University Health Network, Princess Margaret Hospital, 610 University Ave, Toronto, ON, M5G 2M9, Canada |
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| Abstract: | The purpose was to investigate the potential value of apparent diffusion coefficient (ADC) measurement with MRI in the assessment of cervix cancer. Diffusion-weighted MRI was performed in 47 patients with cervical carcinoma undergoing chemoradiation therapy and 26 normal controls on a 1.5-T system with a b-value of 600 s/mm2. FIGO stage, tumor volume, nodal status, interstitial fluid pressure (IFP) and oxygen measurements were recorded. Response was defined as no visible tumor 3–6 months following completion of therapy. The average median ADC (mADC) of cervical carcinomas (1.09±0.20×10−3 mm2/s) was significantly lower than normal cervix (2.09±0.46×10−3 mm2/s) (P<0.001). There was no correlation between mADC, nodal status, tumor volume, IFP or oxygen measurements. mADC was significantly lower in FIGO stages T1b/T2a (0.986 × 10−3 mm2/s) compared to T2b (1.21×10−3 mm2/s) and T3/T4 (1.10×10−3 mm2/s) (P<0.001). In patients with squamous carcinomas the 90th percentile of ADC values was lower in responders than non-responders (P<0.05). Median ADC in cervix carcinoma is significantly lower compared to normal cervix. ADC may have predictive value in squamous tumors, but further long-term study will determine the ultimate clinical utility. |
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| Keywords: | Apparent diffusion coefficient Magnetic resonance Cervical cancer Cervix Uterus |
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