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| 吡柔比星灌注预防浅表性膀胱癌术后复发的临床研究 | |
| 引用本文： | 蒲军,吴小候,唐伟,陈在贤,王德林,何云峰. 吡柔比星灌注预防浅表性膀胱癌术后复发的临床研究[J]. 重庆医学, 2009, 38(17) |
| 作者姓名： | 蒲军 吴小候 唐伟 陈在贤 王德林 何云峰 |
| 作者单位： | 重庆医科大学公共卫生学院,400016;重庆医科大学附属第一医院泌尿外科,400016 |
| 摘 要： | 目的 评价吡柔比星膀胱灌注预防浅表性膀胱癌术后复发的疗效和安全性.方法 将68例浅表性膀胱癌术后患者随机分为2个组,一组患者膀胱灌注羟基喜树碱(HCPT)32例,另一组膀胱灌注吡柔比星(THP)36例,随访6～24个月,观察两组复发情况及不良反应.结果 THP组2年复发率为13.9%,不良反应发生率为63.9%;HCPT组2年复发率为25.0%,不良反应发生率59.4%,比较两组复发率差异有统计学意义(P＜0.05),而两组不良反应发生率差异无统计学意义(P＞0.05).结论 膀胱灌注吡柔比星预防浅表性膀胱癌术后复发的疗效确切,不良反应小,患者耐受性好,是较为理想的膀胱灌注化疗药物. |
| 关 键 词： | 膀胱肿瘤 吡柔比星 羟基喜树碱 复发 |
Clinical study of intravesical pirarubicin instillation for preventing postoperative recurrence of superficial bladder cancer |
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| PU Jun,WU Xiao-hou,TANG Wei,et al.. Clinical study of intravesical pirarubicin instillation for preventing postoperative recurrence of superficial bladder cancer[J]. Chongqing Medical Journal, 2009, 38(17) | |
| Authors: | PU Jun WU Xiao-hou TANG Wei et al. |
| Affiliation: | PU Jun1,WU Xiao-hou2,TANG Wei2,et al.(1.College of Public Health,2.Department of Urology,Chongqing Medical University,Chongqing 400016,China) |
| Abstract: | Objective To evaluate the effect of pirarubicin(THP) by bladder instillation for preventing the superficial bladder cancer recurrence.Methods This study included 68 patients randomized to two groups.THP by bladder instillation was used in the first group(36 patients),HCPT in the second group(32 patients).They were followed up for 6-24 months.The recurrence and side effects were observed and compared between them.Results The recurrence rate in the THP group was 13.9% and that in the HCPT group was 25.0%,ther... |
| Keywords: | bladder neoplasms THP HCPT recurrence |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |