| Study on the Protective Effects of Compound Blood-activating Soup on Bone Marrow Hematopoietic Cells in Acute Radiation Injured Mice |
| |
| 作者姓名： | 刘文励 肖侃艳 周剑锋 何美冬 孙汉英 唐锦治 |
| |
| 作者单位： | Department of Hematology，Tongji Hospital，Tongji Medical University，Wuhan，430030 |
| |
| 摘 要： | ThisprojectwassupportedbyNationalScienceFoundationofChina(No.39670911)andTraditionalChineseMedicineSectionofthePublicHealthDepartmentofHubeiProvince.Ithasbeenknownthattheprominentmanifestationofbonemarrowintheearlyperiodofacuteradiationwasthathematopoieticcellsdecreasedrapidly,venoussinusexpanded,becominghyperemic,andbloodflowwasinstasisll].Onthebasisofthetheoryofblood-activatingandstasiseliminatingofChinesetraditionalmedicine,weusedablood--activatingandstasis--eliminatingChinesedrug,aco…
|
| 收稿时间： | 6 January 1997 |
Study on the protective effects of compound blood-activating soup on bone marrow hematopoietic cells in acute radiation injured mice |
| |
| Liu Wenli,Xiao Kanyan,Zhou Jianfeng,He Meidong,Sun Hanying,Tang Jinzhi.Study on the Protective Effects of Compound Blood-activating Soup on Bone Marrow Hematopoietic Cells in Acute Radiation Injured Mice[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1997,17(4):225-228. |
| |
| Authors: | Liu Wenli Xiao Kanyan Zhou Jianfeng He Meidong Sun Hanying Tang Jinzhi |
| |
| Institution: | (1) Department of Hematology, Tongji Hospital, Tongji Medical University, 430030 Wuhan |
| |
| Abstract: | Summary After irradiation with 8 Gy60Co γ-ray, mice were immediately given intraperitoneal injection of 200 mg 100% compound blood-activating soup twice a day. On the 3rd and 7th day, the P53 gene expression of bone marrow hematopoietic cells in Chinese drug group was found to be higher than that in normal group,
and it was also significantly higher than that in control group. The expression level of GADD153 gene which was not expressed in normal group was much lower in Chinese drug group than that in control group. On the 7th
day after irradiation, the P53 and GADD153 gene expression levels of splenic mononuclear cells were consistent with those
of bone marrow hematopoietic cells both in Chinese drug group and control group. On the 3rd and 7th day, the bone marrow hematopoietic
tissue volume in Chinese drug group was higher than that in control group, with no difference found between the two groups.
While on the 14th day, the difference became significant (P<0.01). The results showed that commonly used blood-activating and stasis-eliminating drugs may strengthen the viability of
hematopoietic cells and promote the rehabilitation of hematopoiesis by inducing wt-P53 expression to block the bone marrow hematopoietic cells in G1 phase, during which DNA could be repaired.
This project was supported by National Science Foundation of China (No. 39670911) and Traditional Chinese Medicine Section
of the Public Health Department of Hubei Province. |
| |
| Keywords: | acute radiation injury hematopoietic cell P_53 gene GADD_153 gene blood-activating and stasis-eliminating Chinese drugs |
| 本文献已被 CNKI SpringerLink 等数据库收录！ |
