| MAGE-12的HLA-A2限制性细胞毒性T淋巴细胞表位肽的预测及其三维结构构建 |
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| 引用本文： | 李艳秋,鲍布和,高默杰,倪兵,吴玉章. MAGE-12的HLA-A2限制性细胞毒性T淋巴细胞表位肽的预测及其三维结构构建[J]. 武警医学院学报, 2012, 21(7): 494-498,F0002 |
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| 作者姓名： | 李艳秋 鲍布和 高默杰 倪兵 吴玉章 |
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| 作者单位： | 1. 武警后勤学院附属医院检验科,天津,300162
2. 第三军医大学全军免疫学研究所,重庆,400038 |
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| 基金项目： | 国家重点基础研究发展规划资助973项目，武警医学院博士启动基金项目，武警医学院附属医院种子基金项目 |
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| 摘 要： | [目的]从理论上分析预测肿瘤抗原MAGE- 12(melanoma antigen- 12)的HLA-A2(histocompatility leukocyte antigen-A2)限制性细胞毒性T淋巴细胞(cytotoxic T lymphocyte,CTL)表位肽并构建其三维结构.[方法]以肿瘤特异性抗原MAGE-12为研究目标,采用超基序法、量化基序法、多项式法、延展基序法与三维结构构建相结合的CTL表位预测方法.[结果]预测出的MAGE-12的表位中有4个符合HLA-A2限制性CTL表位要求.[结论]预测出的4个HLA-A2限制性CTL表位为MAGE-12的表位的可能性较大,经后续实验筛选、鉴定后,可用于基于MAGE-12的肿瘤治疗性多肽疫苗的设计研究.
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| 关 键 词： | 肿瘤抗原 MAGE-12 表位 预测 |
Prediction of CTL-epitopes of tumor antigen MAGE-12 restricted by HLA-A2 molecules and construction of three dimensional configurations |
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| LI Yan-qiu , Bao Bu-he , Gao Mo-jie , NI Bing , WU Yu-zhang. Prediction of CTL-epitopes of tumor antigen MAGE-12 restricted by HLA-A2 molecules and construction of three dimensional configurations[J]. Acta Academiae Medicinae CPAPF, 2012, 21(7): 494-498,F0002 |
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| Authors: | LI Yan-qiu Bao Bu-he Gao Mo-jie NI Bing WU Yu-zhang |
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| Affiliation: | (Department of Clinical Laboratory, Affilited Hospital of Logistics University of Chinese People＇s Armed Police Force, Tianjin 110032, China) |
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| Abstract: | [Objective] To predict the HLA-A2-restricted CTL epitopes of tumor antigen MAGE- 12, and establish the three- dimensional configurations of HLA-A2-restricted CTL binding peptides. [ Methods] Peptide supermotif prediction combinded with, quantitative motif, and extended motifs in peptides binding to HLA-A2 molecules were used to construct the candidates. [Resuls] 4 CTL epitope candidates derived from the antigen MAGE-12 were found. [Conclusion] After identification, the 4 candidates can be used in the design and study of tumortherapeutic peptide vaccine. |
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| Keywords: | Tumor antigen Melanoma antigen-12 Epitope Rediction |
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