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Comparison of Chinese and Western rifapentines and improvement of bioavailability by prior taking of various meals |
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| Authors: | Chan S L Yew W W Porter J H McAdam K P Allen B W Dickinson J M Ellard G A Mitchison D A |
| Institution: | a Hong Kong Department of Health, Chest Services Central Office, Wanchai Polyclinic, Hong Kong, China b Grantham Hospital, Hong Kong, China c Clinical Sciences, London School of Hygiene & Tropical Medicine, London, UK d Department of Infectious Diseases & Bacteriology, Royal Postgraduate Medical School, London, UK e National Institute for Medical Research, London, UK f Department of Medical Microbiology, St. Georges Hospital Medical School, London, UK |
| Abstract: | Bioavailability was measured by rifapentine (RPE) serum concentrations and by the urinary ratio between RPE and creatinine, in specimens obtained 4-50 h after 600 mg RPE preceded by food. The bioavailabilities of RPEs manufactured in China and by a Western manufacturer were similar after a standard English breakfast, and serum concentrations were also similar to those obtained in an earlier Italian study following a complex meal. Although absorption of RPE was unsatisfactory after lipid-rich biscuits or shortbread, absorption after egges and toast was excellent and was nearly as good after a fast-food sandwich. The urinary measure of bioavailability at 26 h appeared as efficient as peak serum estimations at 6, 8 and 26 h. Fast-food sandwiches are being taken before RPE in a current clinical trial of Chinese RPE in Hong Kong. |
| Keywords: | Rifapentine Bioavailability Meals China |
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