柯萨奇B组病毒感染与扩张型心肌病发病关系的研究

为探讨柯萨奇B组病毒(Coxsackie virusgroup B,CBV)与扩张型心肌病(dilated cardio myopathy,DCM)发病的关系,应用逆转录聚合酶链反应(RTPCR)及酶联免疫吸附试验(ELISA)检查39例扩张型心肌病患者(DCM组)外周血中CBVRNA、血清中CBVIgM.结果表明,DCM组外周血CBVRNA,血清中CBVIgM阳性率分别为41.02%、30.76%,对照组分别为7.6%,2.56%,两组比较差别有显着性意义(P<0.05).结果提示,柯萨奇B组病毒感染和(或)持续感染是引起扩张型心肌病的重要原因.

The study on Relationship between infection Coxsackievirus group B(CBV) and Dilated Cardiomyopathy

To investing the relation between infection of coxsackievirus gruoup B and dilated cardiomyopathy.Methods:The 39 case dilated cardiomyopthy patient's CBVRNA in peripheral blood cells and CBVIgM in the sera by RTPCR and ELISA respectively,So were the 26 case health people as control group.Resultes:dill.ated cardiomyopahty patient's positive rates of CBVRNA in peripheral blood cells and CBVIgM in the sera are 41.02% 、30.75%,respectively and the control group's positive rates are 7.6%,2.56%,respectively.The positive rates are significartly different between two groups(P<0.05).Conclusions:CBV infection plays an important role in dilated cardiomyopathy.