Effect of ponsinomycin on cyclosporin pharmacokinetics |
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| Authors: | W. Couet B. Istin P. Seniuta D. Morel L. Potaux J. B. Fourtillan |
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| Affiliation: | (1) Cemaf, Poitiers, Hopital Pellegrin-Tripode, Poitiers, France;(2) Service de Néphrologie, Hopital Pellegrin-Tripode, Bordeaux, France |
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| Abstract: | ![]()
Summary The influence of treatment with ponsinomycin, a new macrolide antibiotic, on the pharmacokinetics of cyclosporin A has been studied in 10 renal transplant patients. The pharmacokinetics of cyclosporin A was investigated at steady state, before and during treatment with ponsinomycin.On average, the blood levels of cyclosporin A were doubled by the macrolide, possibly due to a decrease in elimination or/and to an increase in absorption.Ponsinomycin should be use very carefully in patients treated with cyclosporin A. |
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| Keywords: | Cyclosporin A ponsinomycin pharmacokinetics drug interaction macrolide antibiotic renal transplantation |
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