过氧化物酶体增殖物激活受体α在结直肠癌发病机制中的作用

目的探讨过氧化物酶体增殖物激活受体α（PPARα）在结直肠癌发病机制中的作用。方法对PPARα与结直肠癌的发病机制相关研究的文献进行综述。结果PPARα在结直肠癌发病机制中对结直肠癌细胞增殖、凋亡、分化的作用仍存在争议。结论PPARα有可能参与了结直肠癌细胞增殖、分化、凋亡等的调控过程，但其具体作用机制以及其上、下游的信号通路仍不清楚。此外，PPARα可能参与了结直肠癌部分化疔药物的耐药机制，但其作用也不甚明了。因此，需要更多的研究工作来进一步探究PPARα与结直肠癌的关系：

Role of Peroxisome Proliferator Activated Receptor a in Pathogenesis of Colorectal Cancer

Objective To investigate the role of peroxisome proliferator activated receptor α （PPARα） in the pathogenesis of colorectal cancer. Method The literatures about PPARα and the pathogenesis of colorectal cancer were reviewed and analyzed. Result The relationships of PPARα to the proliferation, apoptosis, and differentiation of colorectal cancer cells in the pathogenesis of colorectal cancer were controversial. Conclusions PPARα might be involved in the regulation of proliferation, differentiation, apoptosis of colorectal cancer cells, but the pathogenesis and the up- and down-stream signal pathways are not elucidated. In additional, PPARα might partly be involved in the mechanism of drug resistance of chemotherapy drugs for coloreetal cancer, but the role is not very clear yet. So more research works need to be done about the relationship of PPARα to pathogenesis of colorectal cancer.