变态反应性支气管肺曲霉病研究进展

变态反应性支气管肺曲霉病(allergic bronchopulmonary aspergillosis,ABPA)与烟曲霉引起的变态反应相关,常发生在哮喘和肺囊性纤维化患者中.ABPA可引起血清总IgE水平升高,外周血嗜酸粒细胞增多,肺浸润和中心性支气管扩张,严重者可导致肺纤维化等肺组织的不可逆破坏.故ABPA的早期明确诊断和及时治疗十分重要.本文将对近年来ABPA的发病机制、临床分期、诊断标准、辅助检查及治疗研究新进展进行介绍.

Advance in research of allergic bronchopulmonary aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) is related with allergic reaction caused by the Aspergillus fumigatus.ABPA often occurs in patients with asthma and pulmonary cystic fibrosis.ABPA can cause an elevated serum eosinophilia and total IgE level,and pulmonary infiltration and central bronchiectasis.Severe cases can lead to irreversible damage of lung tissue,such as pulmonary fibrosis.Therefore,early diagnosis and timely treatment of ABPA is very important.This article reviews the current development of the pathogenesis,clinical stage,diagnostic criteria,laboratory examination and treatment of ABPA in recent years.