| 调节性T细胞在COPD的免疫机制研究进展 |
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| 引用本文： | 陈博,蒋永亮,胡瑞成,朱黎明,曾丹,戴爱国. 调节性T细胞在COPD的免疫机制研究进展[J]. 国际呼吸杂志, 2017, 37(9). DOI: 10.3760/cma.j.issn.1673-436X.2017.09.016 |
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| 作者姓名： | 陈博 蒋永亮 胡瑞成 朱黎明 曾丹 戴爱国 |
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| 作者单位： | 1. 南华大学附属省马王堆医院呼吸内科,长沙,410016;2. 湖南省老年医院呼吸疾病研究所, 长沙,410016;3. 410219,长沙医学院呼吸疾病研究所 |
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| 基金项目： | Science and Technology Plan Foundation of Hunan，Key Foundation of Science and Technology Plan of Hunan(2012SK2006)湖南省科技计划项目，湖南省科技计划重点项目 |
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| 摘 要： | 关于COPD免疫机制的研究目前并不深入,近期发现调节性T细胞(Treg)能负调控COPD的炎症反应,是影响COPD发生发展的重要免疫机制.以下综述不仅总结了Treg细胞的作用机制,包括通过细胞毒T淋巴细胞相关抗原4 (CTLA-4)、免疫抑制因子、IL-2等经典途径,也包括自噬、Sema4a/Nrp1等最新研究热点;还探讨了在COPD中Treg如何通过CTLA-4、Foxp3、miR-199a-5p、CD1c+树突状细胞及T细胞耗竭来发挥作用.
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| 关 键 词： | 慢性阻塞性肺疾病 调节性T细胞 自噬 Sema4a/Nrp1 T细胞耗竭 |
Regulatory T cells in the immune mechanism of COPD |
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| Chen Bo,Jiang Yongliang,Hu Ruicheng,Zhu Liming,Zeng Dan,Dai Aiguo. Regulatory T cells in the immune mechanism of COPD[J]. International Journal of Respiration, 2017, 37(9). DOI: 10.3760/cma.j.issn.1673-436X.2017.09.016 |
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| Authors: | Chen Bo Jiang Yongliang Hu Ruicheng Zhu Liming Zeng Dan Dai Aiguo |
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| Abstract: | The immune mechanism research of chronic obstructive pulmonary disease (COPD) is not thorough at present,the recent findings of regulatory T cells (Treg) can negative control inflammation of COPD,is an important immune mechanisms influence the occurrence and development of COPD.The following this paper not only summarizes the mechanism of action of regulatory T cells,including through CTLA-4,immunosuppression factor,IL-2 classic way,also including autophagy,Sema4a/Nrp1 latest research focus.In COPD Treg are discussed in this article how to through the CTLA-4,Foxp3,miR-199-a-5p,CD1c+ DCs and T cell exhaustion to play a role. |
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| Keywords: | Chronic obstructive pulmonary disease Regulatory T cells Autophagy Sema4a/Nrp1 T cell exhaustion |
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