氟中毒大鼠骨骼X线动态观察及硒的影响

目的 观察氟中毒大鼠骨Ｘ线改变及硒的影响。方法 ２个组Ｗｉｓｔａｒ大鼠饮１．５８和２．６３ｍｍｏｌ／Ｌ氟水；２个组鼠饮氟水加饲２．０ｍｇ／ｋｇ硒饲料。每２个月用钼靶Ｘ线摄骨片共计６次。实验１４个月时测血、尿、骨氟。结果 氟中毒大鼠血、尿骨氟升高。骨Ｘ改变以骨盆骨结构异常出现最早，其次为腰椎、尾骨；前、后肢改变晚且较少；前肢显现骨间膜骨化，且晚于骨结构改变。实验８个月发性早期氟骨症征象。氟加硒大鼠血

Dynamically observed skeletal X-ray in rats with chronic fluorosis and effects of selenium

Objective To observe trend of skeletal radiography in rats with chronic fluorosis and effect of selenium.Methods Two groups of Wistar rats were fed with normal fodder and high concentration of NaF water (1.58,2.63 mmol/L fluorine,F) and two groups with selenite fodder(2.0 mg/kg selenium,Se) and high F for 14 months.The rats were photographed by means of radiography with molybdenum target tubes biomonthly total 6 times and the contents of urine,serum and bone F in the rats were examined in 14 months.Results Urine,serum and bone F in rats with fluorosis increased.Concerning bone X-ray changes,abnormalities were observed first in pelvis,then in lumbar vertebrae,finally in thoracic and pectoral limbes.Early skeletal fluorosis was found in 8 months.There was a positive correlation between concentration of F in drinking water and degree skeletal fluorosis and of abnormal bone struture.After supplement of Se,serum and bone F decreased.Abnormal bone structure and skeletal fluorosis were reduced.Conclusions Pelvie could be refered as essential observation section by radiography and skeletal fluorosis appeared in the middle and late period of fluorosis.Certain concentration of Se could antagonize high F,delay and decrease the occurrence of skeletal fluorosis in rats with fluorosis.