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| The role of DJ-1 in the pathogenesis of Parkinson’s disease | |
| 作者姓名： | Zhi-Quan WANG1 Hai-Yan ZHOU2 Sheng-Di CHEN1 2 1Institute of Health Science Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and Shanghai Jiaotong University School of Medicine Shanghai 200025 China 2Department of Neurology and Institute of Neurology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 China |
| 作者单位： | Zhi-Quan WANG1，Hai-Yan ZHOU2，Sheng-Di CHEN1，2 1Institute of Health Science，Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and Shanghai Jiaotong University School of Medicine，Shanghai 200025，China 2Department of Neurology and Institute of Neurology，Ruijin Hospital，Shanghai Jiaotong University School of Medicine，Shanghai 200025，China |
| 摘 要： | 1 Introduction Parkinson’s disease (PD) is a common neurodegen- erative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars com- pacta (SNpc). Although the majority of the cases appear to be sporadic, the disorder also can be associated with spe- cific genetic defects, several of which have been identified, including α-synuclein, parkin, PINK1, dardarin (LRRK2) and DJ-1[1]. Vincenzo Bonifati et al. localized a gene for autosomal recessive… |
| 关 键 词： | Parkinson’s disease DJ-1 molecular chaperone antioxidative factor |
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