胃癌患者血清肿瘤标志物的特点及临床意义

目的分析胃癌患者血清多种肿瘤标志物的特点,为临床提供胃癌筛查、诊断及动态监测指标。方法采用C-12多种肿瘤标志物蛋白芯片检测系统对129例胃癌术前患者、45例胃癌术后患者、76例胃部良性疾病患者及189例正常体检者的血清进行12种肿瘤标志物检测。并对其进行统计分析。结果胃癌患者血清中CA199(28.7%),NSE(6.2%),CEA(21.7%),CA242(20.2%),HCG(22.5%),AFP(6.2%)及HGH(22.5%)单项指标检出阳性率均高于正常健康者及胃部良性疾病患者(P<0.05);而胃癌术后患者仅CA199(13.3%)和CEA(21.7%)高于正常健康者(P<0.05);胃癌患者血清CA199和CA242水平明显高于胃癌术后患者(P<0.05)。胃癌患者血清单一指标阳性检出率最高为CA199的达28.7%,而联合上述有统计学意义的7项指标阳性检出率高达53.5%,与正常健康者(20.3%),统计学上有显著性意义(P=0.000)。结论多种肿瘤标志物联合检测能提高胃癌患者的阳性检出率,并为胃癌患者治疗效果的动态分析提供客观依据。

The characteristic of tumor markers in sera of patients with gastric carcinoma and clinic significance

Objective To investigate the application of multi-tumor markers protein chip diagnose system in the analyzing, screening and monitoring of gastric carcinoma. Methods Using the multi-tumor markers protein chip diagnose system to determine and analyze the concentration value of 12 tumor markers (NSE,CEA, AFP, CA199, CA125, CA153, CA242, f-PSA, HGH, Beta-HCG and FER) in sera of 129 gastric cancer patients, 45 moved gastric cancer patients, 76 patients with gastric benign diseases and 189 normal individuals. Results The positive rate of tumor markers in sera of patients with gastric carcinoma CA199 (28.7 %), NSE (6.2 %), CEA (21.7 %), CA242 (20.2 %), HCG (22.5 %), AFP (6.2 %) and HGH (22.5 %) was found higher than those of patients with gastric benign diseases and normal individuals (P <0.05). Positive rate of tumor markers CA199 and CA242 in sera of patients with gastric cancer was significantly higher than those of patients with moved gastric cancer (P <0.05), but CEA and CA153 was found significantly lower than those of patients with moved gastric cancer. The highest positive rate of tumor marker CA199 in serum of patients with gastric cancer was 28.7 %, combined another statistics targets, the positive rate of tumor markers in sera of patients with gastric cancer achieved 53.5 %, compared with normal control group (20.3 %), there was a significant difference (P =0.000). Conclusions It can raise screening rate of patients with gastric cancer combined multi-tumor markers determined and can supply objective basis for acting comprehensive analysis of gastric carcinoma.