| 抗菌水凝胶敷料的制备及性能 |
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| 引用本文： | 程惠蕾,周雯婷,郑安呐,郭吟竹,李天一,管涌. 抗菌水凝胶敷料的制备及性能[J]. 医学教育探索, 2014, 27(3) |
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| 作者姓名： | 程惠蕾 周雯婷 郑安呐 郭吟竹 李天一 管涌 |
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| 作者单位： | 华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与应用教育部重点实验室， 上海 200237;华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与应用教育部重点实验室， 上海 200238;华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与应用教育部重点实验室， 上海 200239;华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与应用教育部重点实验室， 上海 200240;华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与应用教育部重点实验室， 上海 200241;华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与应用教育部重点实验室， 上海 200242 |
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| 基金项目： | 上海市自然科学基金项目(12ZR1407800) |
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| 摘 要： | 以乙二醇二缩水甘油醚(GDE)为偶联剂，将胍盐低聚物(PHMG)接枝到淀粉上，形成淀粉接枝物(Starch-g-PHMG)。然后，将一定比例的Starch-g-PHMG与淀粉 丙烯酸接枝共聚物共混，制备了抗菌水凝胶敷料(AHD)。通过红外光谱(FT-IR)、元素分析确定了Starch-g-PHMG的分子结构；通过吸液测试、抗菌测试表征了AHD的理化性能。结果表明:在反应温度为60 °C，反应时间为3 h，w(NaOH) = 0.4%时，Starch-g-PHMG 中PHMG的接枝效率最高，可达37.5%；AHD的吸液率随着Starch-g-PHMG含量的增加而减少；当w(PHMG) > 0.33%时，AHD对金黄色葡萄球菌与大肠杆菌的抑菌率可以达到100%。
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| 关 键 词： | 敷料； 水凝胶； 接枝； 抗菌活性 |
Preparation and Properties of Antimicrobial Hydrogel Dressing |
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| CHENG Hui lei,ZHOU Wen ting,ZHENG An n,GUO Yin zhu,LI Tian yi and GUAN Yong. Preparation and Properties of Antimicrobial Hydrogel Dressing[J]. Researches in Medical Education, 2014, 27(3) |
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| Authors: | CHENG Hui lei ZHOU Wen ting ZHENG An n GUO Yin zhu LI Tian yi GUAN Yong |
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| Affiliation: | Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science andEngineering, East China University of Science and Technology, Shanghai 200237, China;Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science andEngineering, East China University of Science and Technology, Shanghai 200238, China;Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science andEngineering, East China University of Science and Technology, Shanghai 200239, China;Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science andEngineering, East China University of Science and Technology, Shanghai 200240, China;Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science andEngineering, East China University of Science and Technology, Shanghai 200241, China;Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science andEngineering, East China University of Science and Technology, Shanghai 200242, China |
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| Abstract: | Starch grafted oligoguanidine (Starch-g-PHMG) was synthesized using glycol diglycidyl ether as the coupling agent. Antimicrobial hydrogel dressing (AHD) was further prepared by blending Starch-g-PHMG with acrylic acid grafted starch. The molecular structures, physical and chemical properties of the prepared AHD were characterized via Infrared Spectroscopy (FT-IR), element analysis, fluid absorbency tests, and antimicrobial tests. Results showed that the maximum grafting efficiency (37.5%) could be achieved at the optimal reaction conditions as following: 3 h of reaction time at 60 °C and w(NaOH) = 0.4%. The fluid absorbency of AHD decreased with the increasing of Starch-g-PHMG content. The growth inhibition against E. coli and S. aureus reached 100% when w (PHMG) > 0.33%. |
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| Keywords: | dressing hydrogel grafting antimicrobial activity |
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