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Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb,GPIIb/IIIa,and von Willebrand Factor |
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| Authors: | Lars Burdorf Andrea Riner Elana Rybak Isabelle I Salles Simon F De Meyer Aakash Shah Kevin J Quinn Donald Harris Tianshu Zhang Dawn Parsell Franchesca Ali Evan Schwartz Elizabeth Kang Xiangfei Cheng Evelyn Sievert Yuming Zhao Gheorghe Braileanu Carol J Phelps David L Ayares Hans Deckmyn Richard N Pierson III Agnes M Azimzadeh |
| Institution: | 1. Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine and VA Maryland Health Care System, Baltimore, MD, USA;2. Laboratory for Thrombosis Research, IRF‐Ls, Kulak KU Leuven, Leuven, Belgium;3. Centre for Hematology, Imperial College, London, UK;4. Revivicor Inc., Blacksburg, VA, USA |
| Abstract: | |
| Keywords: | coagulation ex‐vivo perfusion Fab GalTKO hCD46 Glycoprotein GPIb GPIIb/IIIa lung platelet activation Xenotransplantation |