低钙高镁饮水与大鼠骨代谢关系

目的 研究低钙高镁饮水对骨代谢的影响及与骨质疏松的发病关系，为山东省黄河入海口居民饮食结构的调整提供科学依据。方法 用低钙、高镁饮水喂养出生1个月的Wistar雌性大白鼠3个月，测定与骨代谢有关的血清生化指标，测量其股骨重量、骨密度，观察骨组织的病理变化。结果 低钙高镁饮水的交互作用使大鼠的骨形成标志物明显增多，股骨发生明显病理变化。结论 钙、镁元素对骨代谢有重要作用，钙元素缺乏不是导致骨质疏松的唯一原因，过量镁元素可引起成长期大鼠的骨丢失。

Effect of low-calcium and high-magnesium drinking water on bone metablism in rats

Objective To investigate the effect of magnesium suppleme nt and calcium depletion drinking water on bone mass loss in rats.Methods Wister female rats received purified dirnking wat er with Mg supplement and Ca deficiency.At 3rd month,blood was collected for ser um Ca,Mg,P,alkaline phosphatase(ALP),BALP and ostecocalsin examination.Then the rats were sacrificed and the femurs were obtained for bone mineral density(BMD)a nd histomorphometry.Results In both high-Mg water group and low--Ca and hi gh Mg water group,serum ALP,BALP and osteocalcin were significantly higher than those of the other two groups,while serum Ca,Mg,P,body weight,weight and BMD of left femo ra did not change significantly medullary area,decreased cortical area and the t rabecular did not change significantly compared with the other two groups.Histom orphometry demonstrated increased medullary area,decreased cortical area and the trabecular bone volume in low-Ca and high-Mg water group.Conclusion Magnesium influenced bone metablism and a low calcium was not the only reason to induce osteoporosis.High magnesium might caus e bone loss of growing rats.