大型自然人群队列示范研究进展与成果题录

中国慢性病前瞻性研究(CKB)项目于2004年6月至2008年8月在5个省(浙江、湖南、甘肃、四川、河南)的农村地区和5个省(自治区)(黑龙江、山东、江苏、广西、海南)的城市地区开展基线调查, 共入选512 891名30～79岁调查对象, 完成问卷调查、体格检查及生物样本收集工作。项目于2008年6-10月开展了19 786人的第一次重复调查, 2013年8月至2014年9月开展了25 239人的第二次重复调查。2016年, 在国家重点研发计划"精准医学研究"重点专项支持下, CKB基于多年工作基础开展了大型自然人群队列示范研究。CKB项目在2020年8月至2021年12月开展了第三次调查, 完成25 087人的调查工作, 包括问卷调查(在基线调查内容上增加了老龄化相关问题)、体格检查以及血液、尿液、唾液、粪便等生物样本采集。截至2022年6月, 项目对全部队列人群平均开展随访已达15年, 累计观察770万人年, 收集死亡事件7.4万人, 医保结局事件37.1万人(累计279.5万人次), 主动随访事件1.1万人(累计1.2万人次), 发病监测事件10.0万人(累计14.7万人次)。C...

Progress and achievements of large natural population cohort demonstration study

China Kadoorie Biobank (CKB) conducted the baseline survey from June 2004 to July 2008 in five rural areas in Zhejiang, Hunan, Gansu, Sichuan and Henan Provinces and five urban areas in Heilongjiang, Shandong, Jiangsu, Guangxi and Hainan Provinces (Autonomous Region). A total of 512 891 adults aged 30-79 years were recruited in the baseline survey, i.e. questionnaire survey, physical examination and blood sample collection. The first resurvey of 19 786 people was conducted from June to October in 2008, and the second resurvey of 25 239 people was conducted from August, 2013 to September, 2014. In 2016, with the support of the "Precision Medicine Research" Key Project, National Key Research and Development Program of China, CKB started a large natural population cohort demonstration study on the basis of the previous work. The third resurvey was conducted from August, 2020 to December, 2021 among 25087 people, including questionnaire survey (with additional aging related items), physical examination and biological sample collection (blood, urine, saliva, stool). By June, 2022, CKB had conducted the follow up in cohort population for an average 15 years, resulting an observation of 7.7 million person-years. which documented 74 000 deaths, 371 000 health insurance events (2.795 million episodes in total), 11 000 active follow-up events (12 000 episodes in total), 100 000 morbidity monitoring events (147 000 episodes). CKB Biobank has stored 1 292 000 blood samples, 150 000 urine samples, 780 000 DNA samples, 25 000 saliva samples, and 20 000 stool samples. CKB project team has developed the technical specifications for long-term follow-up, sample database construction and management, database and data sharing platform construction and management, which have been compiled and published as the Technical Specifications for Large Population Cohort Research. In addition, the group standards of field survey of large natural population cohort, long term follow up, biobank construction, data process and data security have been developed. Meanwhile, high-quality scientific research have been conducted consecutively based on the CKB cohort data, the research of the relationship between healthy lifestyle and major chronic diseases have provided specific evidence in Chinese population.