促性腺激素释放激素激动剂及拮抗剂在体外受精-胚胎移植应用的比较

在促性腺激素释放激素激动剂(GnRH-a)未应用于辅助生殖之前,因垂体提前出现黄体生成素(LH)峰,大约有20%的体外受精(IVF)不得不终止,GnRH-a的应用使不能进行IVF的比率降到2%。由于防止了提前出现的LH峰,使卵泡发育同步化,提高了卵子质量,从而也提高了妊娠率。促性腺激素释放激素

Comparing the application of GnRH agonist and GnRH antagonist in in vitro fertilization and embryo transfer

GnRH agonist(GnRH-a) and GnRH antagonist(GnRH-ant) play important roles in in-vitro fertilization and embryo transfer(IVF-ET).The effect of GnRH-a was affirmed during twenty years'use.The application of GnRH-ant was comparatively less because some advantages of GnRH-a has not been recognized and now researchers pay much attention on it.So,its useness become more and more in the cycles of controlled ovarian stimulation(COS).Up to now,identical conclusion on which kind of the GnRH analogue is more superior for the results of IVF-ET has not been got.As for GnRH-ant,much investigation should be done and a lot of biological rationale and convincing clinic data should be acquired so as to proving which will be better.