| 可控制性卵巢刺激治疗中促性腺激素释放激素激动剂降调节与卵巢过度抑制 |
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| 引用本文： | 李洁,谭真,任姿,庄广伦.可控制性卵巢刺激治疗中促性腺激素释放激素激动剂降调节与卵巢过度抑制[J].生殖医学杂志,2007,16(5):306-308. |
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| 作者姓名： | 李洁 谭真 任姿 庄广伦 |
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| 作者单位： | 中山大学附属第一医院生殖医学中心,广州,510080 |
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| 摘 要： | 基于促性腺激素释放激素激动剂(GnRH-a)短时给药对垂体的激发作用引起血清黄体生成素(LH)和卵泡刺激素(FSH)升高有利于增加卵泡募集,而长期给药导致垂体局部受体脱敏与消耗而有效地抑制排卵前LH峰出现和降低卵泡晚期血清LH水平,从而减少卵泡过早黄素化和取消周期、改善卵子质量
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| 关 键 词： | 促性腺激素释放激素激动剂 卵巢低反应 类固醇生成 |
| 文章编号： | 1004-3845（2007）05-0306-03 |
| 修稿时间： | 2007-08-10 |
Ovarian poor responder correlated with GnRH-a down regulation |
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| LI Jie,TAN Zhen,REN Zhi,ZHUANG Guang-lun.Ovarian poor responder correlated with GnRH-a down regulation[J].Journal of Reproductive Medicine,2007,16(5):306-308. |
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| Authors: | LI Jie TAN Zhen REN Zhi ZHUANG Guang-lun |
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| Abstract: | The retrospective study showed that 87.4%(248/279) ovarian poor responder could be reversed by reduced the dose of GnRH-a or increased initial Gn dose compared with full or a half dose and one third dose of GnRH-a down-regulation groups,only 11.1%(31/279) cases taken place ovarian poor responder again in next IVF-ET cycle.The result implied that profound ovarian suppression could be reversed by reduced GnRH-a dose or increased Gn dose in women with ovarian normal function.The dose of GnRH-a may have an impact on the steroidgenesis in IVF-ET cycles. |
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| Keywords: | GnRH-a Ovarian poor responder Steroidgenesis |
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